黄芪桂枝五物汤治疗神经根型颈椎病的贝叶斯Meta分析OA

Objective:To assess the efficacy and safety of Huangqi Guizhi Wuwu decoction in the treatment of cervical radiculopathy(CR)using Bayesian meta-analysis.Methods:Randomized controlled trials(RCTs)on Huangqi Guizhi Wuwu Decoction for the treatment of CR were retrieved from PubMed,Embase,Cochrane Library,and China National Knowledge Infrastructure(CNKI)databases from their inception to March 2023.Two independent researchers performed literature screening and data extraction.Bias risk assessment was conducted using RevMan 5.3 software,and Bayesian meta-analysis was performed using Stata 14.0 software.Results:A total of 15 randomized controlled trials were included.Bayesian random-effects meta-analysis showed that,compared with other therapies,Huangqi Guizhi Wuwu Decoction significantly improved the total effective rate(SMD=3.58,95%CI:3.18-7.02,P＜0.000 01),VAS scores(SMD=-1.03,95%CI:-1.96--0.10,P=0.03),the scores of symptoms and body signs(SMD=-2.13,95%CI:-3.18--1.08,P＜0.001),and cervical function score(SMD=4.92,95%CI:4.15-5.69,P＜0.001),with low incidence of adverse reactions(SMD=-0.01,95%CI:-0.03--0.01,P=0.47).Conclusion:Huangqi Guizhi Wuwu decoction could improve the clinical efficacy for CR patients,effectively alleviate symptoms,enhance quality of life,and has a favorable safety profile.