桥本氏甲状腺炎患者血清维生素D水平变化与意义OA

Objective:To analyze the changes in serum vitamin D levels in patients with Hashimoto's thyroiditis(HT)and explore the relationship between HT and vitamin D.Methods:A total of 111 patients diagnosed with HT who visited our hospital from October 2022 to October 2023 were selected as the observation group,and 105 healthy individuals undergoing physical examinations were chosen as the control group.The levels of various thyroid function indicators[triiodothyronine(T3),thyroxine(T4),thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),thyroglobulin antibody(TGAb),thyroid microsomal antibody(TMA),anti-thyroid peroxidase antibody(TPOAb])and 25-hydroxyvitamin D[25-(OH)D]were measured,and the results were statistically analyzed.Results:The serum levels of T3,TSH,FT4,TGAb,TMA,and TPOAb in HT patients were significantly higher than those in the control group,while the level of 25-(OH)D was significantly lower(P<0.05).There were no significant differences in serum 25-(OH)D levels among HT patients with different thyroid function statuses(P>0.05).The 25-(OH)D level in HT patients was negatively correlated with TGAb and TMA(P<0.05),and there was no significant correlation with other thyroid function indicators(P>0.05).Conclusion:The serum 25-(OH)D level in HT patients is significantly decreased and is signif-icantly correlated with thyroid autoantibodies TGAb and TMA.It is recommended that HT patients regularly monitor their serum 25-(OH)D lev-els to avoid vitamin D deficiency and delay the progression of the disease.