内质网应激与视网膜疾病的研究进展OA

The retina is indispensable for normal visual function,which relies on massive protein synthesis.As the core organelle gov-erning protein and lipid biosynthesis,the endoplasmic reticulum is primarily responsible for intracellular protein synthesis,folding,translation,assembly,modification and trafficking.Disruptions including Ca2+homeostasis imbalance,ischemia-hypoxia,abnormal blood glucose and gene mutations can induce protein misfolding,thus triggering endoplasmic reticulum stress.Furthermore,endoplasmic reticulum stress mediates in-flammatory response,oxidative stress and apoptosis via activating the unfolded protein response,endoplasmic reticulum overload response and sterol regulatory element-binding protein pathway,contributing to the pathogenesis of multiple retinal diseases.This review summarizes the cor-relation between endoplasmic reticulum stress and common retinal diseases,as well as recent advances in targeted therapeutic interventions.