垂直有序介孔二氧化硅薄膜用于电致化学发光生物传感的研究进展OA

Electrochemiluminescence(ECL)biosensing technology demonstrates significant potential in biomedical analysis and clinical diagnosis due to its high sensitivity,low background signal,and excellent controllability.However,traditional materials commonly encountered problems such as easy leakage of signal molecules,insufficient anti-biocontamination ability,and limited signal amplification capacity for trace target substances during ECL biosensing interface assembly.The vertically-ordered mesoporous silica film(VMSF),as a novel nanostructured material,offers an ideal interface for constructing a new generation of high-performance ECL biosensing by virtue of its highly ordered,vertically arranged nano-channel structure,unique size sieving effect,charge selectivity,high specific surface area,and facile modifiability.This review comprehensively outlines the structural characteristics and preparation methods of VMSF,and the functionalization assembly strategies of VMSF interface in ECL biosensing.Then,the latest application progress of VMSF in the detection of small molecules,tumor markers,nucleic acids,drugs,and cells is systematically summarized.Finally,current challenges and future research directions are discussed,aiming to provide insightful perspectives for the rational design of ECL biosensing based on VMSF.