酒糟血管紧张素转化酶抑制肽调控动物抗氧化和抗炎作用及其高效制备技术研究进展OA

Distiller's grains,a by-product of the brewing industry,are rich in protein and various bioactive components,through processing methods such as enzymatic hydrolysis or microbial fermentation,the angioten-sin-converting enzyme inhibitory peptides(ACEi)can be released.The ACEi exert their effects by inhibiting a key enzyme in the renin-angiotensin-aldosterone system(RAAS),thereby reducing angiotensin Ⅱ(AngⅡ)generation,disrupts the vicious cycle of"oxidative stress-angiotensin-converting enzyme(ACE)-AngⅡ"and AngⅡ-mediated mitochondrial oxidative damage pathways,and disrupts the AngⅡ-triggered nuclear factor-κB(NF-κB)signaling pathway.Moreover,ACEi modulate tumor necrosis factor(TNF)and receptor of ad-vanced glycation end products(RAGE)related pathways,reducing secretion of inflammatory factors and ulti-mately alleviating oxidative stress and inflammatory responses,which shows significant potential in mitigating oxidative stress in livestock and poultry.Therefore,this review summarizes ACEi from various distiller's grain and their preparation methods,and elaborates on the role of ACEi in regulating antioxidant and anti-inflamma-tory responses in animals,furthermore,efficient preparation technologies for ACEi,including enzymatic hy-drolysis,microbial fermentation and DNA recombinant technology,are analyzed.The aim of this review is to provide a theoretical foundation for promoting the application of ACEi from distiller's grains in animal produc-tion and to support the development of novel green feed additives.[Chinese Journal of Animal Nutrition,2026,38(5):3324-3332]