肠道微生物介导的色氨酸代谢及其在畜禽营养中的应用研究进展OA

Tryptophan(Trp)is one of the essential amino acids for livestock and poultry.It is mainly metabo-lized via the kynurenine,5-hydroxytryptamine(5-HT)and indole pathways,and its metabolites play impor-tant roles in immune regulation,anti-oxidative stress and maintenance of intestinal barrier function.The gut mi-crobiota not only directly mediate the metabolic transformation of Trp,but also alter its metabolic flux by regu-lating key enzyme activities and immune signaling pathways,thereby affecting host health.Based on the inter-actions among gut microbiota,Trp metabolism and the host,this review systematically summarizes the mecha-nisms by which Trp improves host health,such as activating the aryl hydrocarbon receptor signaling pathway and promoting 5-HT synthesis,and discusses its effects on the feed intake,growth and development,and prod-uct quality of livestock and poultry.On this basis,it is proposed that future research should focus on the precise supply strategies of Trp at different physiological stages,the functional verification of key metabolites,and the analysis of the molecular regulatory network of microbiota-Trp interaction,so as to optimize gut microbiome-based precision nutrition approaches of Trp in livestock and poultry production.[Chinese Journal of Animal Nutrition,2026,38(5):3257-3270]