慢性肾脏病患者血清Klotho蛋白与心血管疾病的相关性分析OA

Objective To investigate the correlation between serum Klotho protein and the occurrence of cardiovascular disease(CVD)in patients with chronic kidney disease(CKD).Methods We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey(NHANES)from 2009 to 2016.Multivariate logistic regression,subgroup analysis,and propensity score matching were a-dopted to reduce the impact of confounding variables.Results A total of 2 017 patients were enrolled,among whom 504 had comorbid CVD and 1 513 did not.Logistic regression analysis showed that in all three models,elevated Klotho levels were negatively correlated with the incidence of CVD in CKD patients(P<0.05).As Klotho levels increased from the lowest to the highest quartile(Q1 to Q4),the risk of CVD decreased in a gra-dient manner(P<0.05).In Model 3,with Q1 as the reference,the odds ratios(OR)for Q2,Q3,and Q4 were 0.94(95%CI:0.70 to 1.26),0.88(95%CI:0.65 to 1.19),and 0.72(95%CI:0.52 to 0.99),respectively.Subgroup analysis demonstrated that the protective effect of Klotho levels against CVD was more significant in female patients,those aged over 60 years,those with estimated glomerular filtration rate(eGFR)≥60 mL·min-1·(1.73 m2)-1,and those with body mass index(BMI)<28 kg/m2(P<0.05).After propensity score matching and adjustment for confounding factors,Klotho remained an independent protective factor for the occurrence of CVD(P=0.026,OR=0.631,95%CI:0.417-0.942).Conclusion Serum Klotho is an in-dependent protective factor against CVD in CKD patients,and its effect is more pronounced in specific sub-groups.