基于中药品种、品质与药效相关性理论诠释多基原品种的异同性OA

Objective:To explore the scientific connotation of the traditional Chinese medicine(TCM)theory that"similar varieties share consistent quality and analogous efficacy,while different varieties exhibit distinct quality and disparate efficacy"in interpreting the similarities and differences of poly-origin TCMs.Methods:This study took Epimedium brevicornu of different origins for the pre-vention and treatment of osteoporosis as the research object.Methods including database mining,molecular docking combined with net-work pharmacology were adopted to analyze the similarities and differences of poly-origin Epimedium brevicornu.Results:The active ingredients,disease targets and action mechanisms of Epimedium brevicornu species from different origins share similarities while ex-hibiting distinct differences.Conclusion:Which verified the scientificity of the theory of correlation among variety,quality and efficacy of TCM in interpreting the similarities and differences of poly-origin TCMs.This theory can provide scientific guidance for the resource development,precise clinical medication and quality control of poly-origin TCMs.