外周血MHR、NT-proBNP及RDW对急性心肌梗死患者早期恶性室性心律失常发生的预测作用OA

Objective:To explore the levels of peripheral blood monocyte-to-high-density lipoprotein cholesterol ratio(MHR),red blood cell distribution width(RDW)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)and its value and practical significance in early warning of early malignant ventricular arrhythmia(MVA)in patients with acute myocardial infarction(AMI).Methods:200 patients with AMI were retrospectively studied.According to whether early malignant ventricular arrhythmia(MVA)occurred within 48 hours,the enrolled patients were classified into occurrence group(n=26)and non-occurrence group(n=174).After comparing differences in clinical data between groups,multivariate Logistic regression model was utilized to accurately identify risk factors associated with the occurrence of early outcome events(MVA)in AMI.The predictive value of MHR,NT-proBNP and RDW on early MVA was evaluated by receiver operating characteristic(ROC)curve analysis.Results:The proportion of Killip grade III or IV,neutrophil count,monocyte count,RDW,NT-proBNP,MHR,and D-dimer levels in the occurrence group were higher than those in the non occurrence group(P<0.05),the blood potassium level was lower than that of the non occurring group(P<0.05).Multivariate analysis suggested that high levels of MHR,NT-proBNP,RDW and D-dimer,and Killip grade III or IV were independent risk factors causing early MVA(P<0.05).The AUC,sensitivity and specificity of the combination of MHR,NT-proBNP and RDW in predicting early MVA in AMI patients were 0.958,96.15%and 83.91%,respectively,which were higher than those of single prediction(P<0.05).Conclusion:High levels of MHR,NT-proBNP and RDW can predict whether AMI patients are complicated with early MVA,and can provide valuable reference for clinical risk assessment.