中药封包联合抗结核药方案治疗结核性腹膜炎疗效及其对炎症介质水平的影响观察OA
Clinical efficacy of Chinese medicine envelope therapy combined with anti-tuberculosis drug regimen in the treatment of tuberculous peritonitis and its effects on the level of inflammatory mediators
目的 探讨中药封包联合抗结核治疗方案对结核性腹膜炎(TBP)患者的效果及其对炎症介质水平的影响.方法 选取陕西省结核病防治院2022年4月—2023年5月收治的TBP患者170例,采取信封法随机分为对照组、观察组各85例.对照组给予抗结核药物治疗、腹腔穿刺抽液及辅助营养支持等基础治疗,观察组在此基础上联合中药封包辅助治疗.对比2组治疗前后炎症介质[干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、可溶性白细胞介素2受体(SIL-2R)]水平,抽水次数、腹水吸收时间、腹膜厚度,结核病灶吸收情况,疗效及不良反应.结果 观察组临床疗效优于对照组(P<0.05).治疗后,2组IFN-γ、TNF-α、IL-6、SIL-2R水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.01).与对照组比较,观察组抽水次数少、腹水吸收时间短(P<0.01);2组治疗前腹膜厚度比较差异无统计学意义(P>0.05),治疗后观察组腹膜厚度低于对照组(P<0.05).观察组结核病灶吸收有效率高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05).结论 在常规抗结核方案上联合中药封包治疗TBP,能够提高临床疗效,降低炎症介质水平,改善临床症状,降低不良反应发生率.
Objective To investigate the clinical efficacy of Chinese medicine envelope therapy combined with anti-tuberculosis regimen in patients with tuberculous peritonitis(TBP)and its impact on inflammatory mediator levels.Methods A total of 170 TBP patients admitted to Shaanxi Provincial Tuberculosis Prevention and Control Hospital from April 2022 to May 2023 were selected and randomly divided into a control group and an observation group,with 85 cases in each group,using the envelope method.The control group received basic treatment including anti-tuberculosis drug therapy,abdominal paracentesis for ascites drainage,and nutritional support.The observation group received Chinese medicine envelope adjuvant therapy in addition to the treatment given to the control group.Inflammatory mediator levels[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and soluble interleukin-2 receptor(sIL-2R)],number of abdominal paracenteses,ascites absorption time,peritoneal thickness,absorption of tuberculous lesions,clinical efficacy,and adverse reactions were compared between the two groups before and after treatment.Results The clinical efficacy in the observation group was superior to that in the control group(P<0.05).After treatment,the levels of IFN-γ,TNF-α,IL-6,and sIL-2R in both groups were significantly lower than those before treatment(P<0.05),and were lower in the observation group than in the control group(P<0.05).Compared with the control group,the observation group had fewer paracenteses and shorter ascites absorption time(P<0.05).There was no significant difference in peritoneal thickness between the two groups before treatment(P>0.05),while after treatment,peritoneal thickness in the observation group was lower than that in the control group(P<0.05).The effective absorption rate of tuberculous lesions in the observation group was higher than that in the control group(P<0.05),and the incidence of adverse reactions was lower in the observation group than in the control group(P<0.05).Conclusion The combination of Chinese medicine envelope therapy with a conventional anti-tuberculosis regimen in TBP patients can improve clinical efficacy,reduce inflammatory mediator levels,alleviate clinical symptoms,and decrease the incidence of adverse reactions.
李彦鹏;景凤英;张燕;邱峥;王帆;马喜迎;邵小霞;南亚
陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100陕西省结核病防治院中西医结合科,西安 710100
中药封包结核性腹膜炎炎症介质安全性
Chinese medicine envelopetuberculous peritonitisinflammatory mediatorssafety
《北京中医药》 2026 (3)
328-332,5
陕西省中医药管理局委托项目(SZY-KJCYC-2022-YJ,SZY-KJCYC-2023-094)
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