Selectivity and stability reshaping high-sensitivity detection boundaries:A technical leap and paradigm shift in semiconductor surface-enhanced Raman scatteringOA
This perspective commemorates 50 years of surface-enhanced Raman scattering(SERS)by highlighting the paradigm shift toward rationally designed semiconductor substrates,enabling ultrasensitive and moleculeselective detection.Several enhancement strategies have been developed to effectively modulate the electronic band structure and charge transfer(CT)processes,such as energy level customization,amorphization,quasimetallization,and morphology control,achieving high enhancement factors with good selectivity and stability.Moreover,semiconductor SERS substrates show broad prospects in the fields of bio-sensing and cancer diagnosis.Nevertheless,standardization gaps in substrate reproducibility and data comparability hinder its widespread adoption.Resolving these challenges through multi-stakeholder collaboration is essential to bridge the technology transfer gap and establish SERS as a core platform for next-generation inspection.
Jie Lin;Xiangyu Meng;Yujiao Xie;Yusi Peng;Xingce Fan;Kun Liang;Fugang Xu;Aiguo Shen;Libin Yang;Lei Chen;Wei Ji;Tingting Zheng;Teng Qiu;Shan Cong;Zhigang Zhao;Xiaotian Wang;Yong Yang;Aiguo Wu;Guangcheng Xi;Bing Zhao
Laboratory of Advanced Theranostic Materials and Technology,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo 315201,ChinaSchool of Basic Medical Sciences,Hebei University,Baoding 071002,ChinaLaboratory of Advanced Theranostic Materials and Technology,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo 315201,ChinaState Key Laboratory of High-Performance Ceramics and Superfine Microstructures,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,ChinaKey Laboratory of Quantum Materials and Devices of Ministry of Education,School of Physics,Southeast University,Nanjing 211189,ChinaLaboratory of Advanced Theranostic Materials and Technology,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo 315201,ChinaCollege of Chemistry and Materials,Jiangxi Normal University,Nanchang 330022,ChinaSchool of Bioengineering and Health,Wuhan Textile University,Wuhan 430200,ChinaCollege of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,ChinaSchool of Materials Science and Engineering,Jilin Jianzhu University,Changchun 130118,ChinaCollege of Chemistry,Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040,ChinaShanghai Key Laboratory of Green Chemistry and Chemical Processes,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,ChinaKey Laboratory of Quantum Materials and Devices of Ministry of Education,School of Physics,Southeast University,Nanjing 211189,ChinaKey Lab of Nanodevices and Applications,Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,ChinaKey Lab of Nanodevices and Applications,Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,ChinaSchool of Chemistry,Beihang University,Beijing 100191,ChinaState Key Laboratory of High-Performance Ceramics and Superfine Microstructures,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,ChinaLaboratory of Advanced Theranostic Materials and Technology,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo 315201,ChinaKey Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment for State Market Regulation,Chinese Academy of Quality and Inspection&Testing,Beijing 100176,ChinaState Key Laboratory of Supramolecular Structure and Materials,Jilin University,Changchun 130012,China
化学化工
surface-enhanced Raman scatteringsemiconductorenhancement strategiesbio-sensingcancer diagnosis
《Nano Research》 2026 (3)
P.990-994,5
support from the National Natural Science Foundation of China(Nos.12374390,12274018,52473250,and 52501244).
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