Bionic hierarchically ordered structured organic–inorganic composites(BOICs):From materials manufacturing to tissue regeneration engineeringOA
Biominerals,such as bones and teeth,are typically natural organic–inorganic composites characterized by hierarchically ordered structures and exceptional mechanical properties.In contrast,synthetic organic–inorganic composites exhibit inferior structural order,mechanical performance,and bioactivity,which restricts their clinical applicability.Researchers have been inspired to precisely regulate the integration and spatial arrangement of organic matrix(e.g.,collagen,chitosan)and inorganic units(e.g.,calcium phosphate)via mimicking the process of biomineralization to fabricate bionic hierarchically ordered structured organic–inorganic composites(BOICs).These BOICs demonstrate distinguished mechanical properties and biocompatibility,and even perform novel functions,including the bionic bone scaffolds for hard tissue regeneration,bionic mandibular scaffolds for gradient repair,and even as substitutes for tendons.Furthermore,BOICs offer opportunities to study the structural ordering and mechanical properties of artificially enhanced organic–inorganic composites and their effects on biological behaviors of cells.This review systematically summarizes the hierarchically ordered structures and mechanical characteristics of bones and teeth,details current BOICs construction strategies,and highlights their applications in tissue repair.Finally,the current challenges in the development and clinical implementation of BOICs are discussed,with the aim of stimulating innovative ideas and encouraging further developments in tissue regeneration engineering.
Shuxian Zhou;Haiyan Wu;Yadong Yu;Jue Shi;Zhijian Xie;Wenjing Jin
Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Zhejiang Key Laboratory of Oral Biomedical,Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering,Zhejiang Clinovation Pride,Hangzhou 310000,ChinaStomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Zhejiang Key Laboratory of Oral Biomedical,Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering,Zhejiang Clinovation Pride,Hangzhou 310000,ChinaSchool of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,ChinaStomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Zhejiang Key Laboratory of Oral Biomedical,Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering,Zhejiang Clinovation Pride,Hangzhou 310000,ChinaStomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Zhejiang Key Laboratory of Oral Biomedical,Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering,Zhejiang Clinovation Pride,Hangzhou 310000,ChinaStomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Zhejiang Key Laboratory of Oral Biomedical,Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering,Zhejiang Clinovation Pride,Hangzhou 310000,China
医药卫生
bioinspired materialshierarchically ordered structureorganic–inorganic compositestissue regeneration engineering
《Nano Research》 2026 (5)
P.712-731,20
supported by the National Natural Science Foundation of China(No.22207097)the Exploration R&D Program of Stomatological Hospital Affiliated to Zhejiang University School of Medicine(No.RD2023JCYL07)the Key R&D Program of Zhejiang Province(No.2024C03081)Medical Interdisciplinary Innovation Program 2024,Zhejiang University School of Medicinethe Funds of the Central Government Guiding Local Science and Technology Development(No.2023ZY1060)the Funds of Zhejiang Clinovation Pride。
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