Recent advances in anticancer metallodrugs based on gold complexes and clustersOA
In the field of metal-based anticancer agents,gold-based drugs have emerged as one of the most promising research directions following platinum-based drugs,owing to their unique physicochemical properties and distinct anticancer mechanisms.This review introduces Au(I)complexes,Au(III)complexes and gold clusters separately,summarizing the recent advances in the anticancer research of gold complexes and gold clusters with well-defined structures.Special emphasis is placed on the ligand design and structure-activity relationships of Au(I)complexes,the synthetic strategies and anticancer mechanisms of Au(III)complexes,as well as the characteristics of gold cluster drugs.Furthermore,the future development directions of gold-based anticancer agents are prospected,including the development of novel targeted ligands,the combination of cancer therapies,and indepth elucidation of their mechanisms of action.
Xiaoni An;Liang Zhao
The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing 100084,ChinaThe Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing 100084,China
化学化工
Au(I)Au(III)gold clusterscancer therapy
《Nano Research》 2026 (4)
P.567-583,17
Financial support by the National Natural Science Foundation of China(Nos.22025105 and 22350002)Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China(No.JYB2025XDXM413)is gratefully acknowledged.
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