Neuroregulatory effects of combined tDCS and rTMS therapy on major depressive disorder:insights into symptom alleviation and inflammatory modulationOA
Background:Major depressive disorder(MDD)is frequently characterized by elevated inflammatory markers.Transcranial direct current stimulation(tDCS)and repetitive transcranial magnetic stimulation(rTMS)have been studied separately for the alleviation of inflammation levels in MDD.This study aims to investigate the combined neuroregulatory effects of tDCS and rTMS on neuroinflammation in patients with MDD.Methods:This 10-day,parallel-group randomized controlled trial(RCT)involved 88 patients with MDD,with 80 patients ultimately completing the study.Patients were randomly divided into four intervention groups:combination therapy(tDCS combined with rTMS,n=20),tDCS(n=20),rTMS(n=21),and pharmacological(n=19)treatment,and received 10 consecutive days of treatment.The Hamilton Depression Rating Scale(HAMD-17)was used to assess changes in depressive symptoms,and cytokine levels were measured to assess inflammatory status.Results:Compared to baseline,total HAMD-17 scores decreased post-treatment in all four groups.The response rates(χ^(2)=1.660,p=0.646)and remission rates(χ^(2)=5.208,p=0.157)were not significantly different between the four groups.Multivariate logistic regression analysis identified IL-2(p=0.022,OR=0.850,95%CI:0.7400.977)and TNF-α(p=0.006,OR=1.061,95%CI:1.0171.106)levels as being independently associated with the use of combined treatment.Conclusion:All four treatment groups demonstrated comparable short-term efficacy in alleviating depressive symptoms.IL-2 and TNF-αrepresent potential prognostic biomarkers for patients with MDD.
Caiyi Zhao;Zhongheng Lv;Yingying Sun;Liuyan Ren;Juan Li;Jingyang Zhu;Zhangyuan Wang;Mengmeng Zhang;Yuening Li;Chunyan Wu;Nana Wei;Zhaohui Zhang;Juan Wang
Henan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,The Second Affiliated Hospital of Henan Medical University(Henan Mental Hospital),Xinxiang 453200,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,The Second Affiliated Hospital of Henan Medical University(Henan Mental Hospital),Xinxiang 453200,Henan,ChinaHenan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,The Second Affiliated Hospital of Henan Medical University(Henan Mental Hospital),Xinxiang 453200,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Key Laboratory of Neurorestoratology The First Affiliated Hospital of Henan Medical University,Weihui 453100,Henan,ChinaHenan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,The Second Affiliated Hospital of Henan Medical University(Henan Mental Hospital),Xinxiang 453200,Henan,China
医药卫生
Transcranial direct current stimulationTranscranial magnetic stimulationMajor depressive disorderInflammationCytokine
《Journal of Neurorestoratology》 2026 (2)
P.49-58,10
supported by the Research and Innovation Support Project for Postgraduates of Xinxiang Medical University(YJSCX202355Y)Henan Provincial Science and Technology Research Project(LHGJ20230531)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(YJS2021JD12).
评论