iMARS:Advancing artificial multienzyme architecture design through rational approachesOA
Biocatalysis underpins cellular metabolism and industrial biomanufacturing,with multienzyme cascades widely applied in pharmaceuticals,food,and chemicals.Natural enzyme complexes achieve efficiency through precise spatial organization,enabling substrate channeling,minimizing diffusion and side reactions,and reducing product inhibition.Artificial assemblies—enzyme fusions,protein,nucleic acid,and nanomaterial scaffolds—enhance cascade efficiency but remain poorly understood and rely on trial-and-error[1].
Ting Wu;Jie Zhou;Akihiko Kosugi;Weiliang Dong
State Key Laboratory of Materials-Oriented Chemical Engineering,College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,ChinaState Key Laboratory of Materials-Oriented Chemical Engineering,College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,China Key Laboratory for Waste Plastics Biocatalytic Degradation and Recycling,Nanjing 211816,ChinaBiological Resources and Post-Harvest Division,Japan International Research Center for Agricultural Sciences(JIRCAS),Ibaraki 305-8686,JapanState Key Laboratory of Materials-Oriented Chemical Engineering,College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,China Key Laboratory for Waste Plastics Biocatalytic Degradation and Recycling,Nanjing 211816,China
生物科学
rational approachesnanomaterial scaffolds enhancecellular metabolismreducing product inhibitionartificial assemblies enzyme fusionsproteinnucleic acidandsubstrate channelingminimizingartificial multienzyme architecturemultienzyme cascadesprecise spatial organizationenabling
《Green Carbon》 2026 (1)
P.104-106,3
supported by the National Key Research and Development Program of China(Grant No.2024YFC3908303)the National Natural Science Foundation of China(Grant No.22278219)Basic Research Program of Jiangsu(Grant No.BK20233003)Post-graduate Research&Practice Innovation Program of Jiangsu Province(Grant No.SJCX250628).
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