From morphology to function:Advances in multimodal imaging for pulmonary function predictionOA
Pulmonary function test(PFT)is a vital noninvasive method for evaluating respiratory system function and is widely used in the diagnosis,surgical risk assessment,and prognostic prediction of chronic airway diseases and interstitial lung diseases.In 2021,the American Thoracic Society and the European Respiratory Society updated their pulmonary function interpretation guidelines,choosing to adopt z-scores instead of percentage of predicted forced expiratory volume in 1 second(FEV1),thereby significantly improving sensitivity and prognostic evaluation.However,conventional PFT relies on patient cooperation and is limited in its ability to effectively capture the heterogeneity of localized lesions.In recent years,the use of multimodal medical imaging in pulmonary function prediction has progressed rapidly.When combined with radiomics and deep learning techniques,these imaging methods enable more accurate and quantitative functional assessments.This review introduces that pulmonary function assessment should integrate multimodal imaging features with clinical functional indicators.This approach establishes cross-scale linkages between morphology and function and provides new perspectives for the early screening of high-risk individuals with accelerated pulmonary aging,evaluating the effectiveness of interventions,and enabling personalized intervention strategies.We review the classification systems and clinical value of PFT,discuss the advances and limitations of multimodal imaging in predicting lung function,and explore future directions in standardized data acquisition and multicenter validation to promote precise pulmonary function assessment and clinical application.
Yaoting Zhu;Shuhong Guan;Jianxiong Gao;Yan Sun;Jinbao Feng;Yuhao Fan;Mengyue Hu;Yunmei Shi;Yuetao Wang;Rong Niu;Jun Zhou;Xiaonan Shao
Department of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Respiratory and Critical Care Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,ChinaDepartment of Respiratory and Critical Care Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,ChinaDepartment of Nuclear Medicine,The Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213003,China Institute of Clinical Translation of Nuclear Medicine and Molecular Imaging,Soochow University,Changzhou Jiangsu 213003,China Changzhou Clinical Medical Center,Changzhou Jiangsu 213003,China
医药卫生
Pulmonary function testMultimodal imagingRadiomicsDeep learningPulmonary function prediction
《Intelligent Oncology》 2026 (2)
P.66-77,12
supported by Top Talent of Changzhou’s“The 14th Five-Year Plan”High-Level Health Talents Training Project(Grant No.:2022CZBJ037,2024CZBJ008)Key Laboratory of Changzhou High-tech Research Project(Grant No.:CM20193010)Changzhou Science and Technology Program(Grant No.:CJ20220228)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.:SJCX25_1794,SJCX25_1795)Changzhou Clinical Medical Center(Nuclear Medicine)(Grant No.:CZZX202204)Major Project of Changzhou Health Commission(Grant No.:ZD202405)Social Development Project of Changzhou Science and Technology Bureau(Grant No.:CE20235057).
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