Preventive effects of Gan-Du-Qing on respiratory function and life quality in individuals affected by traffic-related air pollution:a randomized,double-blind,placebo-controlled clinical studyOA
Background:Gan-Du-Qing(GDQ),a traditional herbal formula containing Astragali radix(Huangqi)and Belamcandae rhizoma(Shegan),is used for respiratory disorders,but evidence for protecting against PM2.5-related lung impairment is limited.This study evaluated GDQ on pulmonary function and quality of life in individuals exposed to PM2.5 and explored potential mechanisms.Methods:In a randomized,double-blind,placebo-controlled trial,sanitation workers(high exposure)and indoor staff from an Environmental Protection Bureau(low exposure)received GDQ or placebo for 4 weeks and were followed for 12 weeks with two follow-up visits.Outcomes included vital signs,pulmonary function,SF-36,COOP/WONCA,and gut microbiota profiling by 16S rRNA.Results:In the high-exposure group,GDQ improved pulmonary function,SF-36 and COOP/WONCA scores,and mitigated gut microbiota dysbiosis.PM2.5 exposure was associated with restrictive ventilatory changes.While between-group differences were not significant immediately post-intervention,FEV1,FEF50%,and FEF75%improved at the second follow-up,suggesting a delayed benefit.High exposure increased gut microbial diversity and abundance,which were partially reduced after GDQ(P<0.05).Conclusion:GDQ may alleviate PM2.5-related chronic pulmonary injury,potentially via anti-inflammatory and immunomodulatory effects mediated by gut microbiota modulation.
Zhen-Xing Wang;Xiao-Min Wang;Cai-Xia Pei;De-Mei Huang;Zhe-Rui Shen;Fei Wang;Shi-Hua Shi;Yi-Lan Wang;Yong-Can Wu
Institute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaInstitute of Geriatrics of Traditional Chinese Medicine,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,ChinaCollege of Chinese and Modern Medicine,Chongqing University of Traditional Chinese Medicine,Chongqing 402760,China
医药卫生
PM2.5microbiotalung injuryherbal medicineGan-Du-Qing
《Traditional Medicine Research》 2026 (9)
P.5-14,10
funded by National Natural Science Foundation of China(82305171,82474500,82505498,82505500)Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine(2023MS555,2024YFFK0148)Joint Project of Chongqing Natural Science Foundation and Municipal Education Commission(CSTB2025NSCQ-LZX0100)Science and Technology Research Project of Chongqing Education Committee(KJQN202300436)Chongqing University of Traditional Chinese Medicine Sanqi Famous Teachers Promotion Project(SQMX2024QNXM-004)Chongqing Postdoctoral Special Support(2024CQBSHTB2012).
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