Validation of the CRAFITY score for predicting prognosis in patients with hepatocellular carcinoma undergoing transarterial chemoembolization combined with systemic therapyOA
Background The CRAFITY score can predict survival and radiological response to systemic front-line treatment in patient with hepatocellular carcinoma(HCC).Aims In this study,we aimed to externally validate the CRAFITY score and compare it with other simple prognostic models in patients with unresectable HCC who underwent transarterial chemoembolization(TACE)combined with systemic therapies.Methods Patients with unresectable HCC who underwent TACE combined with tyrosine kinase inhibitors(TKIs),with or without immune checkpoint inhibitors(ICIs),were retrospectively analyzed to determine whether the CRAFITY score can predict overall survival(OS)through multivariate analysis and Kaplan‒Meier curves.Prediction of 3-and 6-month objective response rates(ORRs)was validated by the area under the curve(AUC).Results Among 147 patients with unresectable HCC,113 received TACE+TKI and 34 received TACE+TKI+ICI.The CRAFITY score was identified as an independent predictor for OS(P<0.001)and showed a good ability to categorize all included patients into low-,moderate-,and high-risk groups(P<0.001).For predicting the 3-and 6-month ORRs,the CRAFITY score exhibited poor performance,with AUCs of 0.555 and 0.515,respectively.Conclusion The CRAFITY score is effective in predicting OS but demonstrates limited accuracy in predicting 3-and 6-month ORRs for patients with unresectable HCC undergoing TACE combined with systemic therapies.
Haifeng Zhou;Jianwu Ren;Feida Wu;Wei Yang;Di Zhu;Yuguan Xie;Qi Shi;Zhongling Pei;Yan Shen;Lingling Wu;Sheng Liu;Haibin Shi;Weizhong Zhou
Department of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,ChinaDepartment of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,No.300 Guangzhou Road,Nanjing,210029,China
医药卫生
Transarterial chemoembolizationHepatocellular carcinomaPrognosis predictionTyrosine kinase inhibitorImmune checkpoint inhibitor
《Journal of Interventional Medicine》 2025 (1)
P.3-9,7
supported by the Jiangsu Provincial Innovative and Entrepreneurial Doctor Program(303073543ER21)to Haifeng Zhouthe National Natural Science Foundation of China(81701802)to Weizhong Zhou and the Jiangsu Province Capability Improvement Project through ScienceTechnology and Education(JSDW202243)to Haibin Shi.The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.
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