Advances in benzaldehyde lyase-catalyzed biotransformations:From enzyme engineering to industrial applicationsOA
Benzaldehyde lyase(BAL),a thiamine diphosphate(ThDP)-dependent enzyme requiring divalent cations(e.g.,Mg^(2+)),mediates enantioselective C-C bond formation and cleavage to exclusively produce(R)-configuredα-hydroxy ketones.Recent integration of rational enzyme design,materials science,and green chemistry innovations has significantly broadened BAL''s catalytic versatility.These advances establish BAL as a pivotal tool in sustainable chiral synthesis,enabling efficient construction of high-value molecules for medicinal chemistry,agrochemicals,and advanced materials.This review highlights BAL''s emerging applications in biotransformation over the last fifteen years(2010-2025),including multi-enzyme combinations and multidisciplinary collaborations.It presents groundbreaking results that provide both theoretical foundations and scalable solutions for pharmaceutical and industrial processes.
Zhiyun Li;Junwei Huang;Bingrong Chen;Shilong Dou;Xiaoxia Liu;Wei Zhu;Zhiran Ju;Fener Chen
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs,State Key Laboratory of Green Chemical Synthesis and Conversion,Zhejiang University of Technology,Hangzhou 310000,ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs,State Key Laboratory of Green Chemical Synthesis and Conversion,Zhejiang University of Technology,Hangzhou 310000,ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs,State Key Laboratory of Green Chemical Synthesis and Conversion,Zhejiang University of Technology,Hangzhou 310000,ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs,State Key Laboratory of Green Chemical Synthesis and Conversion,Zhejiang University of Technology,Hangzhou 310000,ChinaZhejiang Hisoar Pharmaceutical Co.,LTD,Taizhou 318000,ChinaFuan Pharmaceutical Group Pharmaceutical Co.,LTD,Chongqing 401254,ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs,State Key Laboratory of Green Chemical Synthesis and Conversion,Zhejiang University of Technology,Hangzhou 310000,China Zhejiang Hisoar Pharmaceutical Co.,LTD,Taizhou 318000,ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs,State Key Laboratory of Green Chemical Synthesis and Conversion,Zhejiang University of Technology,Hangzhou 310000,China Engineering Center of Catalysis and Synthesis for Chiral Molecules,Fudan University,Shanghai 200433,China
化学化工
Benzaldehyde lyaseα-hydroxy ketonesChiral synthesisBiotransformation
《Green Synthesis and Catalysis》 2026 (2)
P.138-156,19
supported by Zhejiang Provincial Natural Science Foundation of China under Grant No.LTGY23B020003.
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