Intelligent enzyme design and hybrid catalytic systems:Driving innovation in biocatalysisOA
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis,environmental remediation,and green chemistry.It is undergoing a transformative shift,propelled by the synergistic integration of artificial intelligence(AI)and innovative hybrid catalytic strategies.This review provides a comprehensive overview of recent progress in the field,emphasizing the optimization and advantages of enzyme-based catalytic systems.It examines how AI has revolutionized enzyme design,enabling unprecedented precision and efficiency.Furthermore,the integration of enzymatic catalysis with thermochemical,photochemical,and electrochemical principles is discussed,highlighting synergistic strategies that enhance reaction performance and expand application scope.Together,the convergence of AI-guided design with chemo-enzymatic,photoenzymatic,and electroenzymatic strategies is forging a new frontier in biocatalysis,offering sustainable and efficient solutions to synthetic challenges across pharmaceuticals,green chemistry,and renewable energy.Finally,the review considers the implications of these developments for sustainable industrial practices and suggests promising avenues for future research.
Ge Qu;Fangrui Zhong;Jian Xu;Xiaoqiang Huang;Zhoutong Sun
Hubei Hongshan Laboratory,College of Life Science and Technology,Huazhong Agricultural University,Wuhan 430070,ChinaHubei Key Laboratory of Bioinorganic Chemistry&Materia Medica,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan 430074,ChinaState Key Laboratory of Green Chemical Synthesis and Conversion,College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014,ChinaState Key Laboratory of Coordination Chemistry,Chemistry and Biomedicine Innovation Center,School of Chemistry and Chemical Engineering,Frontier Interdisciplinary Science Research Center,Nanjing University,Nanjing 210023,ChinaState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China National Technology Innovation Center of Synthetic Biology,Tianjin 300308,China
化学化工
Enzyme engineeringAI-Guided enzyme designChemo-enzyme catalysisPhoto-enzyme catalysisElectro-enzyme catalysis
《Green Synthesis and Catalysis》 2026 (2)
P.157-174,18
supported by the National Key R&D Program of China(No.2024YFA1510500 to F.Z.)the Fundamental Research Funds for the Central Universities(No.KG202503 to X.H.)National Natural Science Foundation of China(No.22322705 to J.X.,and No.32171474 to G.Q.)Natural Science Foundation Applying system of Tianjin(No.21JCJQJC00110 to Z.S.).
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