N-heterocyclic nitrenium-catalyzed photoreductive radical-polar crossover for alkene dicarbofunctionalizationOA
The photoredox radical-polar crossover paradigm is a valuable tool for 1,2-difunctionalization of alkenes.However,the use of unactivated alkyl halides as radical precursors remains far less developed.Here,we report a photoreductive N-heterocyclic nitrenium-catalyzed radical-polar crossover for the 1,2-dicarbofunctionalization of alkenes by using unactivated alkyl and aryl iodides.These reactions can be carried out under simple,transition-metal-free conditions with easily obtainable materials such as alkyl/aryl halides,alkenes,and aldehydes.The reactions exhibit a broad range of substrate compatibility and good tolerance towards functional groups.This approach offers a new tool to unlock the compatibility of carbon skeletons.
Youfeng Han;Beibei Zhang;Zhixiang Wang;Xiangyu Chen
School of Chemical Sciences,University of Chinese Academy of Sciences(UCAS),Beijing 100049,ChinaSchool of Chemical Sciences,University of Chinese Academy of Sciences(UCAS),Beijing 100049,ChinaSchool of Chemical Sciences,University of Chinese Academy of Sciences(UCAS),Beijing 100049,China Binzhou Institute of Technology,Weiqiao-UCAS Science and Technology Park,Binzhou 256606,ChinaSchool of Chemical Sciences,University of Chinese Academy of Sciences(UCAS),Beijing 100049,China Binzhou Institute of Technology,Weiqiao-UCAS Science and Technology Park,Binzhou 256606,China Beijing National Laboratory for Molecular Sciences,Beijing 100190,China
化学化工
Radical-polar crossoverN-heterocyclic nitreniumDicarbofunctionalizationAlkenes
《Green Synthesis and Catalysis》 2026 (2)
P.175-181,7
Supported by the National Natural Science Foundation of China(Nos.22173103,22001248 and 2023M733459)the Fundamental Research Funds for the Central Universities and the University of the Chinese Academy of Sciences and Beijing National Laboratory for Molecular Sciences(No.BNLMS2023014).
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