化痰散结方联合隔物灸对肝郁痰凝型乳腺囊性增生病患者激素水平的影响OA
The Effect of Huatan Sanjie Formula Combined with Indirect Moxibustion on Hormone Levels in Patients of Cystic Hyperplasia of Breast with Liver Depression and Phlegm Coagulation Pattern
目的 观察化痰散结方联合隔物灸对肝郁痰凝型乳腺囊性增生病患者激素水平的影响.方法 选择驻马店市中医院收治的符合纳入标准的肝郁痰凝型乳腺囊性增生病患者,采用简单随机抽样法随机分为对照组和观察组,每组各40例,研究过程中对照组脱落1例,观察组脱落2例.对照组给予常规治疗,观察组给予化痰散结方联合隔物灸治疗,均治疗3个月经周期.比较两组患者治疗前后乳房肿块、乳房胀痛、胸胁胀满等中医症状评分和总积分,乳房肿块评分(肿块大小、肿块硬度、肿块疼痛),血清激素雌二醇(E2)、孕酮(P)、泌乳素(PRL)水平和生活质量(QOL)评分的变化情况.结果 治疗后,两组乳房肿块、乳房胀痛、胸胁胀满等中医症状评分和总积分,乳房肿块评分,血清E2、PRL水平显著降低(P<0.05),P水平显著升高(P<0.05);且观察组上述指标的改善情况均优于对照组(P<0.05).结论 化痰散结方联合隔物灸能有效调节肝郁痰凝型乳腺囊性增生病患者激素水平,纠正雌/孕激素(E/P)比例失衡,从而减轻患者临床症状,缓解疼痛,促进肿块吸收,提高患者生活质量.
Objective To observe the effect of Huatan Sanjie Formula combined with indirect moxibustion on hormone levels in patients of cystic hyperplasia of breast with liver depression and phlegm coagulation pattern.Methods Patients of cystic hyperplasia of breast with liver depression and phlegm coagulation pattern who were admitted to Zhumadian Traditional Chinese Medicine Hospital and met the inclusion criteria were enrolled.They were randomly divided into a control group and an observation group using simple random sampling,with 40 cases in each group.During the study,1 case in the control group and 2 cases in the observation group dropped out,respectively.The control group received conventional treatment,while the observation group was treated with Huatan Sanjie Formula combined with indirect moxibustion.Both groups were treated for 3 menstrual cycles.The traditional Chinese medicine(TCM)symptom scores and total scores for breast mass,breast distending pain,and hypochondriac fullness were compared between the two groups before and after treatment.Changes in breast mass scores(size,consistency,and pain),serum levels of estradiol(E2),progesterone(P),prolactin(PRL),and quality of life(QOL)scores were compared between the two groups before and after treatment.Results After treatment,the TCM symptom scores and total scores for breast mass,breast distending pain,and hypochondriac fullness,breast mass scores,serum E2 and PRL levels in both groups were significantly decreased(P<0.05),while serum P level was significantly increased(P<0.05).The improvement of the above indicators in the observation group was better than that in the control group(P<0.05).Conclusion Huatan Sanjie Formula combined with indirect moxibustion can effectively regulate hormone levels,correct the imbalance of estradiol/progesterone(E/P)ratio in patients of cystic hyperplasia of breast with liver depression and phlegm coagulation pattern,thereby alleviating clinical symptoms and pain,promoting mass absorption,and improving the QOL of patients.
宁伟;海艺贝
驻马店市中医院,河南 驻马店 463000驻马店市中医院,河南 驻马店 463000
化痰散结方隔物灸乳腺囊性增生病肝郁痰凝证乳癖激素水平
Huatan Sanjie FormulaIndirect moxibustionCystic hyperplasia of breastLiver depression and phlegm coagulation patternBreast lumpHormone levels
《中医药信息》 2026 (5)
55-59,5
河南省中医药科学研究专项课题(2024ZY2209)
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