儿童非酒精性脂肪性肝病中医证型与体成分相关性分析OA

Objective:To investigate the characteristics of body composition and nutritional status across different Traditional Chinese Medicine(TCM)syndrome patterns in children with non-alcoholic fatty liver disease(NAFLD),providing objective evidence for TCM-based prevention and treatment.Methods:A total of 204 NAFLD children aged 7-18 years from the TCM outpatient clinic of Beijing Children's Hospital were enrolled and classified into four groups based on TCM syndrome differentiation:liver depression and spleen deficiency(LDSD),dampness turbidity retention(DTR),damp-heat accumulation(DHA),and phlegm-stasis intermingling(PSI).Body composition parameters were measured using a bioelectrical impedance analysis(BIA)device,and intergroup differences were statistically analyzed.Results:The LDSDgroup(38.24%)and DTRgroup(32.35%)accounted for the highest proportions among NAFLD children.The PSI group exhibited significantly higher values in body weight,waist circumference,hip circumference,waist-to-hip ratio(WHR),body mass index(BMI),visceral fat area(VFA),and fat-free mass index(FFMI)compared to the LDSD group(P<0.05).BMI,VFA,and FFMI showed an increasing trend across the four groups(LDSD<DHA<DTR<PSI),with statistically significant differences between the LDSD and PSI groups(P<0.05).No significant differences were observed in total body water or skeletal muscle mass among groups.Conclusion:TCM syndrome patterns in pediatric NAFLD correlate with distinct body composition features.The progressive increase in BMI,VFA,and FFMI across syndrome patterns suggests that disease progression from LDSD to PSI is accompanied by aggravated metabolic disturbances.