肌肉脂肪比例、体脂率与非肥胖型非酒精性脂肪性肝病的相关性OA

Objective:To investigate the correlation between muscle-to-fat ratio(MFR),body fat percentage(BFP)and non-obese non-alcoholic fatty liver disease(NAFLD)and their predictive value.Methods:Non-obese adults who participated in health checkups at Xiyuan Hospital of the China Academy of Traditional Chinese Medicine from 1 January 2021 to 31 December 2024 were enrolled in this study,and the baseline level was compared based on the presence or absence of NAFLD as a grouping basis;the correlation between the MFR and BFP and the prevalence of NAFLD in the non-obese population was analysed by using R 4.2.0 and EmpowerRCH 4.2;Interaction tests were performed based on gender,age,smoking history and previous disease history;the diagnostic predictive efficacy of MFR and BFP for NAFLD in the non-obese population was assessed and compared using receiver operating characteristic(ROC)curves.Results:A total of 1 045 non-obese samples were included in this study.After logistic regression correction for 20 confounders such as age,gender,smoking history,etc.,the likelihood of being diagnosed with NAFLD was reduced to 0.02 times for every 1-unit increase in MFR and 1.28 times for every 1-unit increase in BFP in non-obese individuals,respectively.Subgroup analyses showed that increasing MFR and decreasing BFP resulted in more benefit for women and the young and middle-aged group.ROC results showed that the Area under the curve(AUC)of MFR(0.780 7)was higher than that of BFP(0.7715),and there was a statistical difference between the two,with MFR having a superior diagnostic value,with an optimal threshold value of 1.121.Conclusion:MFR,BFP and the prevalence of NAFLD in the non-obese population showed a significant non-linear negative and positive correlation,respectively,and all of them have good diagnostic efficacy,and can be used for the early identification of NAFLD in the non-obese population.