老年急性心力衰竭合并虚弱表型患者线粒体功能障碍与心肌能量代谢的交互作用研究OA

Objective To study the interaction between mitochondrial dysfunction and myocardial energy metabolism in elderly patients with acute heart failure(AHF)combined with weakness phenotype.Methods A total of 80 elderly patients with AHF combined with weakness phenotype who were treated in Jinhua Central Hospital from January 2021 to June 2025 were selected as AHF combined with weakness group,80 elderly patients with AHF without weakness phenotype were selected as AHF group,and 80 healthy people undergoing physical examination were selected as healthy group.The indexes of myocardial energy metabolism[free fatty acids(FFA),left ventricular end systolic wall stress(cESS),myocardial energy expenditure(MEE)],mitochondrial gene copy number(mtDNA-CN),mitochondrial membrane potential,ratio of red fluorescence to green fluorescence(R/G)reactive oxygen species(ROS),adenosine triphosphate(ATP)were detected,and the correlation between mitochondrial dysfunction and myocardial energy metabolism was analyzed.Results The fluorescence intensities of FFA,cESS,MEE and ROS in AHF combined with weakness group were higher than those in AHF group and healthy group,while the relative value of mtDNA-CN,R/G value of mitochondrial membrane potential and ATP content in AHF combined with weakness group were lower than those in AHF group and healthy group(P<0.05).In elderly patients with AHF combined with weakness phenotype,the relative value of mtDNA-CN,the R/G value of mitochondrial membrane potential and the content of ATP were negatively correlated with FFA,cess and mee,and the fluorescence intensity of ROS was positively correlated with FFA,cESS and MEE(P<0.05).Conclusion Elderly patients with AHF combined with weakness phenotype have obvious mitochondrial dysfunction,which is closely related to the abnormality of myocardial energy metabolism.