Sirtuins家族调控骨骼肌萎缩作用机制的研究进展OA

Skeletal muscle atrophy is a degenerative condition with a reduction in the number of muscle fibers or structural destruction as the core pathological feature,and the imbalances in protein synthesis and degradation and mito-chondrial dysfunction are closely associated with the disease.In recent years,the incidence of the disease has been on the rise,which seriously reduce the quality of life of patients.The Sirtuins family as a group of histone deacetylases dependent on nicotinamide adenine dinucleotide activity,play important roles in the regulation of cellular metabolism,oxidative stress,autophagy and mitochondrial dysfunction.Studies have shown that members of this family are involved in the regu-lation of skeletal muscle pathology through multiple signaling pathways and are potential targets for the treatment of skeletal muscle atrophy.In this article,progress on the regulation of skeletal muscle atrophy by the sirtuins family and its related molecular mechanisms were reviewed aiming at providing new ideas for skeletal muscle atrophy and its prevention and treatment strategies.