老年脆性骨折患者血钙与血红蛋白水平的相关性分析OA

Objective To investigate the correlation between serum levels of calcium and hemoglobin(HGB)in the elderly patients with vertebral and non-vertebral fragility fractures,and analyze the prevalence of hypocalcemia and anemia.Methods The patients with fragility fractures who were hospitalized in Honghui Hospital,Xi'an Jiaotong University from January 2020 to August 2023 were enrolled in the study.Participants were categorized into a vertebral fracture group or a non-vertebral fracture group(including hip,proximal humerus and forearm fractures).Pearson cor-relation and partial correlation analysis were performed to evaluate the association between serum calcium level and HGB level.The chi-square test was used to compare the prevalence of hypocalcemia and anemia in patients with vertebral and non-vertebral fractures.Results Totally 14 786 patients with vertebral fractures and 16 017 patients with non-vertebral fractures were enrolled in the study.The mean serum calcium level was significantly higher in the vertebral fracture group(2.28 mmol/L)than in the non-vertebral fracture group(2.21 mmol/L,P＜0.000 1).Serum HGB levels were significantly higher in the vertebral fracture group than in the non-vertebral fracture group(P＜0.001).After adjustment for potential confounders,a significant positive correlation was observed between serum calcium and HGB levels in the overall cohort(r=0.425,P＜0.001).This positive correlation remained significant in both fracture groups upon strati-fied analysis.When fracture site was additionally included as a confounding factor,the correlation coefficient decreased(r=0.390)but remained statistically significant(P＜0.001).Moreover,the prevalences of hypocalcemia and anemia were significantly lower in the vertebral fracture group than the non-vertebral fracture group(P＜0.000 1).Conclusion Among the elderly patients with fragility fractures,serum calcium level is positively correlated with HGB level,and frac-ture site appears to be a contributing factor.Patients with non-vertebral fractures exhibit a higher prevalence of hypocal-cemia and anemia than those with vertebral fractures.These findings underscore the importance of routine monitoring of serum calcium and HGB levels in non-vertebral fracture patients to mitigate potential risks associated with hypocalcemia and anemia.