基于张伯礼"湿浊痰饮类病"理论探讨心血管事件链的机理和防治OA
Mechanism and Prevention of the Cardiovascular Event Chain Based on Zhang Boli's Theory of"Dampness-Turbidity-Phlegm-Fluid Related Diseases"
心血管疾病(CVDs)是全球主要死亡原因之一,给社会和医疗系统带来巨大压力.传统心血管疾病的治疗侧重于症状缓解,但对早期和隐匿阶段的干预较为忽视,中后期治疗也存在一定局限性.张伯礼教授"湿浊痰饮类病"理论基于长期临床实践,系统把握湿浊痰饮津液异化后演变规律和致病机制,与心血管事件链中病情发生发展相契合.CVDs 早期湿邪发病隐匿,发生代谢紊乱导致血管内皮功能障碍,宜用芳香类中药见湿早治;中期痰浊壅塞血脉,从功能失调转变为器质损害,需用升清降浊、化痰散郁之法;后期阴邪久积,引发心肾衰竭,此时应温通阳气,利水消肿.本文详细分析了心血管事件链的不同阶段与"湿浊痰饮类病"的病证相关性,为心血管疾病早期干预和多维度治疗的临床思路,及中医药综合防治提供了新的视角和策略.
Cardiovascular diseases remain a leading cause of death worldwide,imposing a significant burden on both society and healthcare systems.Conventional approaches to treating cardiovascular diseases primarily focus on symptom management,often overlooking early-stage and subclinical interventions.Based on long-term clinical observation,Professor Zhang Boli's theory of"dampness-turbidity-phlegm-fluid related diseases"systematically elucidates the pathological evolution and pathogenic mechanisms following the abnormal transformation of body fluids,aligning closely with the progression of the cardiovascular event chain.The theory posits that in the early stages of cardiovascular diseases,fluid pathogens manifest insidiously,leading to metabolic disturbances and vascular endothelial dysfunction,which warrant early intervention with aromatic herbs.In the middle stage,phlegm-turbidity obstructs the blood vessels,shifting from functional impairment to structural damage,necessitating therapeutic methods to clear vessels,descend turbidity,resolve phlegm,and disperse stagnation.In the late stage,prolonged accumulation of Yin pathogens may trigger heart and kidney failure,requiring treatments to warm and unblock Yang Qi,promote diuresis,and reduce edema.This study systematically analyzes the correlation between the stages of the cardiovascular event chain and the pathological characteristics described in the theory of"dampness-turbidity-phlegm-fluid related diseases",providing novel clinical perspectives and multidimensional strategies for early intervention and comprehensive management of cardiovascular diseases.
李懿霖;秦广宁;徐强;路美娟;李承贤;黄明;王启隆
天津中医药大学中医药研究院,天津 301617天津中医药大学中医药研究院,天津 301617天津中医药大学第二附属医院,天津 300250天津中医药大学第二附属医院,天津 300250天津中医药大学中医药研究院,天津 301617天津中医药大学中医药研究院,天津 301617天津中医药大学中医药研究院,天津 301617
医药卫生
湿浊痰饮类病心血管事件链发病机制治疗
Dampness-turbidity-phlegm-fluid related diseasesCardiovascular event chainPathogenesisTreatment
《中国中医基础医学杂志》 2026 (5)
966-970,5
国家重点研发计划项目(2022YFC3501805)国家自然科学基金面上项目(82474310)
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