静息态fMRI对脊髓损伤患者自发性脑活动改变的分析OA

Objective:To investigate the spontaneous brain activity changes in patients with spinal cord injury by resting-state fMRI.Methods:43 patients with spinal cord injury were prospectively enrolled as the injury group,and 43 healthy volunteers matched in age,sex and education level were recruited as the control group.All subjects underwent resting-state fMRI,and regional homogeneity(ReHo)and fractional amplitude of low-frequency fluctuation(fALFF)analyses were performed,respectively.Two-sample t-test was used to compare the differences between groups.Results:Compared with the control group,the injury group showed brain functional reorganization.The ReHo values in the right middle frontal gyrus and Brodmann 9 area increased significantly,while the ReHo values in the bilateral orbital medial frontal gyri,Brodmann area 10,the left orbital inferior frontal gyrus and left insula decreased significantly.The fALFF values of the right superior parietal gyrus and the right postcentral gyrus increased significantly,while the fALFF values of the right precuneus and left posterior cingulate gyrus significantly decreased.Conclusion:The changes in spontaneous neuronal activity in the brain regions related to sensory-motor networks and cognitive control in patients with spinal cord injury provide important imaging evidence for understanding the neural plasticity after spinal cord injury.