1990-2021年出生时窒息和外伤导致的新生儿脑病疾病负担趋势分析OA

Objective To describe the temporal trends in the disease burden of neonatal encephalopathy due to birth asphyxia and trauma in China and globally from 1990 to 2021,including changes in incidence,prevalence,mortality,and disability-adjusted life years(DALYs).The study also compares the disease burden between China and the global average,and further analyzes the disease burden across regions with varying levels of the socio-demographic index(SDI).Methods This study,based on the publicly available data the Global Burden of Disease(GBD)database(1990-2021).The age-standardized incidence rate(ASIR),age-standardized prevalence rate(ASPR),age-standardized mortality rate(ASMR),and age-standardized DALY rate(ASDR)of neonatal encephalopathy due to birth asphyxia and trauma in China and worldwide were analyzed.The Joinpoint regression model was applied to calculate the average annual percent change(AAPC)and its 95％CI,quantifying the temporal trends in disease burden.Comparative analyses were performed across regions and time periods to provide a comprehensive assessment of the burden of neonatal encephalopathy caused by birth asphyxia and trauma in China relative to global patterns.Results Between 1990 and 2021,the ASIR of neonatal encephalopathy due to birth asphyxia and trauma in China declined from 19.872 to 13.999 per 100 000,while the global ASIR decreased from 20.223 to 17.158 per 100 000.The ASPR in China increased from 158.157 to 333.691 per 100 000,and the global ASPR rose from 129.731 to 242.033 per 100 000.Both in China and worldwide,ASMR and ASDR exhibited marked declines over the study period.In China,the AAPC values for ASIR,ASPR,ASMR,and ASDR were-0.8％,+2.5％,-6.2％,and-5.0％,respectively;globally,the corresponding AAPCs were-0.5％,+2.0％,-1.1％,and-1.0％.As the SDI level increased from low to a moderately high level,the prevalence of neonatal encephalopathy progressively rose and plateaued or slightly declined at high SDI levels.In high-SDI regions,improved survival may have contributed to an increased number of surviving infants living with the condition.Conclusions From 1990 to 2021,the overall disease burden of neonatal encephalopathy due to birth asphyxia and trauma showed a declining trend in both China and globally.Nevertheless,the burden remains substantial in regions with middle to high SDI levels.Neonatal encephalopathy due to birth asphyxia and trauma continues to pose a major public health challenge in China and globally.