基于糖脂代谢紊乱与衰老双向调控的临床干预进展OA

As the aging of the population continues to accelerate,aging has become an important public health issue nowadays.An in-depth analysis of the core regulatory mechanisms of aging and exploring scientifically effective interventional strategies have become the key focus in current research.Disorders of glucose and lipid metabolism are not only a core metabolic feature of the aging process,but also form a vicious cycle of bidirectional regulation with the aging process.Age-related dysfunction of the metabolic regulatory network can induce insulin resistance,mitochondrial dysfunction,and other abnormalities,ultimately disrupting the homeostasis of glucose and lipid metabolism.Conversely,metabolic remodeling further accelerates the decline of tissue and organ function by intensifying oxidative stress,activating chronic inflammation,and inducing cellular senescence.These processes,in turn,drive the onset and progression of age-related diseases including cardiovascular disease,type 2 diabetes,and metabolic dysfunction-associated fatty liver disease(MAFLD).Based on the bidirectional interaction between aging and metabolic dysregulation,this paper systematically reviews clinical intervention studies targeting glucose and lipid metabolism through key bidirectional molecular mechanisms.The review encompasses lifestyle modifications(diet,exercise,sleep),classical and novel pharmacotherapies(metformin,glucagon-like peptide-1 receptor agonists,sodium-glucose cotransporter 2 inhibitors,etc),and emerging targeted therapies.These insights aim to provide evidence-based guidance and clinical translation strategies for the precision prevention and treatment of age-related diseases.