能量代谢与衰老的研究进展OA

Energy metabolism serves as the fundamental basis for sustaining life activities,with its dynamic changes being intrinsically linked to organismal aging.As age advances,the efficiency of energy metabolism progressively declines,accompanied by significant alterations in mitochondrial function,metabolic signaling pathways,and metabolite-mediated epigenetic modifications.This process further compromise cellular function,tissue homeostasis,and overall health,thereby driving the onset of aging and related diseases.Modulating energy metabolism has been shown to ameliorate glucose and lipid metabolism,enhance cellular autophagy and mitochondrial function,and reduce oxidative stress,thereby exerting anti-aging effects and mitigating aging-associated pathologies.Integrating emerging technologies to enable dynamic monitoring of energy metabolism and precise intervention in the aging process represents a pivotal direction for future research.