基于分子分型的子宫内膜癌肿瘤免疫微环境OA

Endometrial cancer(EC)ranks among the three major gynecologic malignancies in women,with its incidence trending stages upward consistently on a global scale and the disease predominantly affecting postmenopausal women.Patients diagnosed at an early demonstrate relatively optimistic survival expectations,whereas those with advanced disease face concerning prognoses.Current therapeutic regimens encompass surgical resection,radiotherapy,chemotherapy,endocrine modulation and other modalities.For advanced,metastatic and recurrent cases,the options for adjuvant therapy are relatively limited.As an immunogenetic disease,the pathogenesis of endometrial cancer is profoundly regulated by the tumor immune microenvironment—a concept substantiated by numerous investigations.A finding that has been validated by numerous studies.At present,the molecular classification system has been established as the core criterion for EC subtyping,yet the characteristics of the tumor immune microenvironment corresponding to different molecular subtypes of EC remain to be elucidated.This paper systematically reviews the cutting-edge research findings on the tumor immune microenvironment characteristics of each molecular subtype of EC,with the aim of providing some assistance for clinical diagnosis and treatment of endometrial cancer.