替罗非班联合西洛他唑治疗早期神经功能恶化穿支动脉粥样硬化型脑梗死的有效性OA
Efficacy of Tirofiban Combined with Cilostazol in the Treatment of Perforator Artery Atherosclerosis Cerebral Infarction with Early Neurological Deterioration
目的:探讨替罗非班联合西洛他唑治疗早期神经功能恶化穿支动脉粥样硬化型脑梗死的有效性及安全性.方法:回顾性收集 70 例 2024 年 1 月—2025 年 9 月于无锡市新吴区新瑞医院神经内科住院治疗的穿支动脉粥样硬化型脑梗死并在院内出现早期神经功能恶化的患者为研究对象,根据不同治疗方案分为两组,每组 35 例.对照组采用替罗非班联合氯吡格雷及阿司匹林治疗,观察组采用替罗非班联合西洛他唑及阿司匹林治疗.比较两组神经功能缺损情况、日常生活能力、疗效及不良反应发生情况.结果:观察组治疗 14、30 d 后的 NIHSS 评分及治疗 30 d 后的改良 Rankin 量表(mRS)评分较对照组低(P<0.05);治疗 30 d 后,观察组总有效率较对照组高(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:对于穿支动脉粥样硬化型脑梗死,替罗非班联合西洛他唑的治疗优势明显,能够改善此类患者的临床预后,且安全性好.
Objective:To explore the efficacy and safety of Tirofiban combined with Cilostazol in the treatment of perforator artery atherosclerosis cerebral infarction with early neurological deterioration.Method:Seventy patients with perforator artery atherosclerosis cerebral infarction who experienced early neurological deterioration during hospitalization at the Department of Neurology,Wuxi Xinwu District Xinrui Hospital from January 2024 to September 2025 were retrospectively collected as the study subjects and divided into two groups according to different treatment plans,with 35 cases in each group.The control group received Tirofiban combined with Clopidogrel and Aspirin,the observation group received Tirofiban combined with Cilostazol and Aspirin.The neurological deficits,daily living abilities,therapeutic effects and the occurrence of adverse reactions were compared between the two groups.Result:The NIHSS scores after 14 and 30 days of treatment and the modified Rankin scale(mRS)score after 30 days of treatment of the observation group were lower than those of the control group(P<0.05).After 30 days of treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For perforator artery atherosclerosis cerebral infarction with early neurological deterioration,the treatment with Tirofiban combined with Cilostazol has significant advantages,it can improve the clinical prognosis of such patients and is also safe.
张炜炜;高晴;贾续东;程婧;罗志威;梁华峰
无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)神经内科 江苏 无锡 214000无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)神经内科 江苏 无锡 214000无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)神经内科 江苏 无锡 214000无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)神经内科 江苏 无锡 214000无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)神经内科 江苏 无锡 214000无锡市新吴区新瑞医院(上海交通大学医学院附属瑞金医院无锡分院)神经内科 江苏 无锡 214000
替罗非班西洛他唑早期神经功能恶化穿支动脉粥样硬化型脑梗死
TirofibanCilostazolEarly neurological deteriorationPerforator artery atherosclerosis cerebral infarction
《中国医学创新》 2026 (11)
40-44,5
无锡市"太湖人才计划"高端医学专家团队项目(WXTHRC2024)上海交通大学医学院附属瑞金医院无锡分院院级课题(2025YJYB002)
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