疏肝解郁安神汤联合重复经颅磁刺激治疗帕金森病合并失眠(肝气郁结型)患者的临床效果OA
Clinical Effect of Shugan Jieyu Anshen Decoction Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Patients with Parkinson's Disease Complicated with Insomnia(Liver Qi Stagnation Type)
目的:探讨帕金森病(PD)合并失眠(肝气郁结型)患者采用疏肝解郁安神汤联合重复经颅磁刺激(rTMS)治疗的临床效果.方法:选取 2024 年 9 月—2025 年 7 月鄂州市中医医院收治的 80 例PD 合并失眠(肝气郁结型)患者,根据随机数字表法分为研究组(n=40)与对照组(n=40).对照组采用 rTMS 治疗,研究组采用疏肝解郁安神汤联合 rTMS 治疗,两组均治疗 1 个月.比较两组临床疗效、中医证候积分、睡眠质量、PD 症状、多导睡眠监测参数、神经因子指标.结果:研究组治疗 1 个月后的总有效率为 95.00%(38/40),较对照组的 77.50%(31/40)高(P<0.05).两组治疗 1 个月后的中医证候积分、帕金森病睡眠量表-2(PDSS-2)、帕金森病统一评分量表(UPDRS)评分较治疗前降低,且研究组较对照组低(P<0.05).两组治疗 1 个月后的睡眠潜伏期(SL)较治疗前缩短,睡眠效率(SE)较治疗前升高,睡眠总时间(TST)较治疗前延长,觉醒次数(AT)较治疗前减少,且相较对照组,研究组SL短,SE高,TST长,AT少(P<0.05).两组治疗 1 个月后的 5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平较治疗前升高,且研究组较对照组高(P<0.05).结论:PD合并失眠(肝气郁结型)患者采用疏肝解郁安神汤联合rTMS治疗,能够提高临床效果,减轻临床症状,改善睡眠质量,调节神经因子水平.
Objective:To explore the clinical effect of Shugan Jieyu Anshen Decoction combined with repetitive transcranial magnetic stimulation(rTMS)in the treatment of patients with Parkinson's disease(PD)complicated with insomnia(liver Qi stagnation type).Method:A total of 80 patients with PD complicated with insomnia(liver Qi stagnation type)from September 2024 to July 2025 who were admitted to Ezhou Hospital of Traditional Chinese Medicine were selected and divided into the study group(n=40)and the control group(n=40)according to the random number table method.The control group received rTMS treatment,and the study group received Shugan Jieyu Anshen Decoction combined with rTMS treatment.Both groups were treated for one month.The clinical efficacy,TCM syndromes scores,sleep quality,PD symptoms,polysomnography parameters,and neurotrophic factors indicators in both groups were compared.Result:The total effective rate of the study group after 1 month of treatment was 95.00%(38/40),which was higher than 77.50%(31/40)of the control group(P<0.05).After one month of treatment,the scores of TCM syndromes,Parkinson's disease sleep scale-2(PDSS-2),and unified Parkinson's disease rating scale(UPDRS)in both groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).After one month of treatment,sleep latency(SL)in both groups were shortened compared to before treatment,sleep efficiency(SE)were increased compared to before treatment,total sleep time(TST)were prolonged compared to before treatment,and awakening times(AT)were reduced compared to before treatment,and compared to the control group,SL in the study group shorter,SE higher,TST longer,and AT fewer(P<0.05).After one month of treatment,the levels of 5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)in both groups were higher than those before treatment,and those in the study group were higher than those in the control group(P<0.05).Conclusion:The combination of Shugan Jieyu Anshen Decoction and rTMS in the treatment of patients with PD complicated with insomnia(liver Qi stagnation type)can improve clinical effect,alleviate clinical symptoms,improve sleep quality,and regulate the levels of neurochemical factors.
刘晓
鄂州市中医医院脑病科 湖北 鄂州 436000
帕金森病失眠疏肝解郁安神汤重复经颅磁刺激
Parkinson's diseaseInsomniaShugan Jieyu Anshen DecoctionRepetitive transcranial magnetic stimulation
《中国医学创新》 2026 (11)
18-22,5
湖北省中医药管理局中医药科研项目(ZY2025L085)
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