血塞通注射液辅助治疗AIS-LVO患者效果及对脑血流动力学、神经相关因子水平的影响OA
Impact of Xuesaitong Injection as Adjuvant Therapy on Cerebral Hemodynamics and Levels of Nerve-Related Factors in Patients with AIS-LVO
目的:探究血塞通注射液辅助治疗大血管闭塞型急性缺血性脑卒中(AIS-LVO)患者的效果,以及对脑血流动力学指标、神经营养因子水平的影响.方法:回顾性分析本院2023年11月至2024年10月收治的100例AIS-LVO患者的临床资料,根据治疗方案不同分为两组.对照组48例患者采用依达拉奉右莰醇注射液治疗,研究组52例患者在对照组基础上,联合血塞通注射液辅助治疗.对比两组患者的疗效,治疗前与治疗14 d后脑血流动力学指标[平均血流速率(Vm)、外周阻力(Rv)、平均血流量(Qm)、动态阻力(DR)]、改良Rankin量表(mRS)评分、美国国立卫生研究院卒中量表(NIHSS)评分、神经相关因子[胶质纤维酸性蛋白(GFAP)、S100钙结合蛋白β(S100β)、神经营养因子3(NT-3)、脑源性神经营养因子(BDNF)]、氧化应激反应[丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)]水平,以及治疗后不良反应发生率.结果:研究组治疗总有效率84.62％(44/52),较对照组 66.67％(32/48)高(P＜0.05);治疗 14 d 后,研究组 Vm、Qm、血清 NT-3、BDNF、GSH-Px 水平较对照组高,Rv、DR、mRS、NIHSS评分及血清GFAP、S100β、MDA水平较对照组低(P＜0.05);两组不良反应发生率比较,差异无统计学意义(P＞0.05).结论:在依达拉奉右莰醇注射液治疗AIS-LVO患者基础上,联合应用血塞通注射液辅助治疗能有效提升疗效,调节神经营养因子水平,改善脑血流动力学及神经功能水平,缓解机体氧化应激反应,而且安全性较高.
Objective:To explore the efficacy of xuesaitong injection as adjuvant therapy for patients with acute ischemic stroke due to large vessel occlusion(AIS-LVO),as well as its impact on cerebral hemodynamics and neurotrophic factor levels.Methods:The clinical data of 100 AIS-LVO patients in our hospital(from November 2023 to October 2024)were retrospectively collected and divided into two groups according to different treatment schemes.48 patients in the control group were treated with edaravone and dexborneol injection,and 52 patients in the study group were treated with xuesaitong injection on the basis of the control group.The efficacy and incidence of adverse reactions were compared between the two groups,as well as the levels of cerebral hemodynamics indicators[mean blood flow rate(Vm),peripheral resistance(Rv),mean blood flow(Qm),dynamic resistance(DR)],modified Rankin scale(mRS)score,National Institutes of Health Stroke Scale(NIHSS)score,nerve-related factors[glial fibrillary acidic protein(GFAP),S100 calcium-binding protein β(S100β),neurotrophic factor 3(NT-3),brain-derived neurotrophic factor(BDNF)],oxidative stress response[malondialdehyde(MDA),glutathione peroxidase(GSH-Px)]were compared between the two groups before the treatment and 14 d after the treatment.Results:The total effective rate of the study group was 84.62％(44/52),which was higher than that of the control group[66.67％(32/48)](P＜0.05).After 14 d of treatment,the levels of Vm,Qm,serum NT-3,BDNF and GSH-Px of patients in the study group were higher than those in the control group,and the Rv,DR,mRS,NIHSS scores and serum GFAP,S100β and MDA levels were lower than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:In the treatment of AIS-LVO patients,on the basis of edaravone and dexborneol injection treatment,the combined application of xuesaitong injection can effectively improve the curative effect,regulate the levels of nerve-related factors,improve the levels of cerebral hemodynamics and nerve function,alleviate the oxidative stress reaction of the body,and have high safety.
王凤歌;杨丙伟
平顶山市第二人民医院宝丰分院,河南平顶山 467400平顶山市第二人民医院宝丰分院,河南平顶山 467400
医药卫生
血塞通注射液大血管闭塞型急性缺血性脑卒中神经相关因子不良反应脑血流动力学氧化应激
Xuesaitong injectionAIS-LVONerve-related factorsAdverse reactionsCerebral hemodynamics
《中国药物评价》 2026 (2)
138-142,5
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