基于"病-药-量"的山药现代用药规律及其在糖尿病肾病中的应用研究OA

Objective:This study systematically screened Chinese herbal prescriptions containing Shanyao(Rhizoma Dioscoreae)from Chinese and English literature databases and utilized data mining techniques to uncover its medication rules,aiming to provide references and evidence for the clinical application of Shanyao,especially its precise application in diabetic kidney disease.Methods:Using"Shan-yao"as the subject term,Chinese and English literature databases including CNKI,Wanfang,VIP,and PubMed were searched to screen out effective prescriptions containing Shanyao.Statistical software IBM SPSS Modeler 18 and SPSS Statistics 26 were employed to analyze the compatibility of medicines,indications and clinical dosage of Shanyao in the included prescriptions.Network pharmacology technology was further applied to analyze the potential role of Shanyao in the treatment of diabetic kidney disease.Results:A total of 804 modern prescriptions containing Shanyao were included,covering 150 indications.The top five high-frequency diseases(≥25 occurrences)were primarily Wasting-Thirst,Diarrhea,Edema,Uterine Bleeding and Vertigo.The corresponding syndrome patterns were Qi and Yin Defi-ciency,Spleen-Stomach Deficiency,Spleen-Kidney Yang Deficiency,Kidney Yin Deficiency and Kidney Essence Deficiency,respective-ly.The compatible herbs were primarily Qi-tonifying medicines,Yang-tonifying medicines and Blood-tonifying medicines.The four natures were mainly Warm,Neutral,Cold and Cool.The five flavors were mainly Sweet,Bitter,Pungent,and Bland.The primary meridian tropism were the Spleen,Kidney,Lung and Liver meridians.For treating Wasting-Thirst,the core herb pairs for Shanyao were"Shanyao-Shanzhuyu(Fructus Corni)-Danshen(Salviae Miltiorrhizae)",with a common dosage of 15 g for Shanyao,emphasizing its effect in nourishing Yin,tonifying the Kidney,promoting fluid production,and quenching thirst.For Edema,the core herb pair was"Shanyao-Fuling(Poria)",with a common dosage of 15 g for Shanyao,highlighting its role in nourishing Yin,tonifying the Kidney,strengthening the Spleen,and allenating edema.For Diarrhea,the core herb pairs were"Shanyao-Baizhu(Rhizoma Atractylodis Macro-cephalae)-Gancao(Radix et Rhizoma Glycyrrhizae)",with a common dosage of 10 g for Shanyao,focusing on its action in strengthening the Spleen,boosting Qi,and stop diarrhea.For Uterine Bleeding,the core herb pairs were"Shanyao-Shanzhuyu(Fructus Corni)-Baishao(Radix Paeoniae Alba)",emphasizing Shanyao's function in nourishing Yin,nourishing Blood,and relieving pain.For Vertigo,the core herb pair was"Shanyao-Shanzhuyu(Fructus Corni)",with a common dosage of 30 g for Shanyao,underscoring its effect in nourishing Yin,tonifying the Kidney,and relieving vertigo.Using network pharmacology,the potential active components and pharmaco-logical mechanisms of Shanyao in treating diabetic kidney disease were further explored.It suggested that compounds such as Hancinol,Kadsurenone,Piperlonguminine,Cholesterol,and Diosgenin might target key targets like PIK3CA,SRC,PIK3CD,PIK3CB,and PTPN11 through pathways like ERK/MAPK,JAK1/2,and PI3K/Akt,thereby potentially alleviating inflammatory responses,regulating insulin resistance,and exerting therapeutic effects.Conclusion:Through data mining,this study systematically summarizes the modern application of Shanyao.Furthermore,network pharmacology reveals the potential mechanisms of Shanyao in treating diabetic kidney disease,which can provide references for its clinical promotion.