氯氮平所致心肌炎的临床特点及危险因素(综述)OACHSSCD
A review of clinical characteristics and risk factors associated with clozapine-induced myocarditis
氯氮平所致心肌炎(CIM)是氯氮平治疗精神分裂症过程中一种罕见但严重的不良反应.近年来,CIM因其严重后果而受到关注,但迄今为止,其危险因素尚未完全明确,且在监测和治疗方面尚未形成广泛认可的共识和指南,导致临床中难以进行针对性预防.本研究回顾了 CIM的临床特点,系统总结如氯氮平不良代谢状态、快速滴定、种族遗传等潜在危险因素,旨在为临床预防和治疗 CIM提供参考.
Clozapine-induced myocarditis(CIM)is a rare but potentially life-threatening adverse reaction associated with clozapine treatment for schizophrenia.In recent years,growing attention has been paid to CIM due to its severe clinical outcomes.However,its specific risk factors remain unclear,and no widely accepted consensus or guidelines have been established for its monitoring and management,making targeted prevention and management in clinical practice difficult.This paper summarizes the clinical characteristics of CIM and systematically analyzes potential risk factors,including clozapine metabolic abnormalities,rapid titration,and genetic or racial predisposi-tions,with the aim to provide references supporting the clinical prevention and management of CIM.
李米尔;丁娈媚;赵海强;行浩然;张盈盈;鲍天昊
云南省精神病医院,昆明医科大学附属精神卫生中心科教部,昆明 650224云南省精神病医院,昆明医科大学附属精神卫生中心科教部,昆明 650224云南省精神病医院,昆明医科大学附属精神卫生中心科教部,昆明 650224云南省精神病医院,昆明医科大学附属精神卫生中心科教部,昆明 650224云南省精神病医院,昆明医科大学附属精神卫生中心科教部,昆明 650224云南省精神病医院,昆明医科大学附属精神卫生中心科教部,昆明 650224
医药卫生
氯氮平氯氮平所致心肌炎临床特点危险因素精神分裂症综述
clozapineclozapine-induced myocarditisclinical characteristicsrisk factorsschizophreniare-view
《中国心理卫生杂志》 2026 (6)
485-490,6
国家自然科学基金(821602698236027582160272)
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