首发未吸烟精神分裂患者外周犬尿氨酸通路的特点OACHSSCD

Objective:To investigate peripheral alterations of neuroactive metabolites in kynurenine pathway(KP)and their associations with psychiatric symptoms in non-smoking patients with first episode schizophrenia(FENS).Methods:Eighty-two FENS and 73 normal controls were recruited.Serum concentrations of kynurenine(KYN),kynurenic acid(KYNA),and quinolinic acid(QUIN)were measured using a combination of liquid chro-matography with tandem mass spectrometry.The Positive and Negative Syndrome Scale(PANSS)was used to as-sess Psychopathology.The t-test and analysis of covariance(ANCOVA)was used to comparison serum levels of product of Kynurenine metabolic pathway between patients with FENS and normal controls.The χ2 test was per-formed to examine differences in categorical variables between the two groups.Pearson's correlations were used to test the associations between variables in two groups respectively.Results:Serum levels of KYN(251.5±65.9 ng/mL),KYNA(5.2±2.2 ng/mL),QUIN(39.5±13.0 ng/mL)in FENS were significantly lower than those in normal controls(KYN,320.7±65.9 ng/mL;KYNA,13.3±4.2 ng/mL;QUIN,58.8±16.9 ng/mL)(t=-6.38,-14.73,-7.67,Ps＜0.001).In FENS patients,Serum KYNA of FENS patients was positively correlated with the general pathological scale of PANSS scale(r=0.30,P＜0.01).Conclusion:FENS patients show signifi-cant abnormalities in peripheral KP metabolites,which are associated with psychiatric symptoms.These findings suggest that KP dysregulation may contribute to the pathophysiology of schizophrenia.