抑郁症脑前额叶与颞叶激活特征及其与临床症状和认知功能的关系OACHSSCD

Objective:To investigate cognitive function of patients with major depressive disorder(MDD),ex-amine frontotemporal lobe hemodynamic responses during the verbal fluency text(VFT)task in patients with MDD,and explore their correlation with depressive symptoms,anxiety symptoms,and severity of cognitive dysfunc-tion.Methods:Forty MDD patients and 40 normal controls matched by age,gender and years of education were en-rolled.The Hamilton Depression Scale(HAMD),Beck Depression Inventory(BDI),Hamilton Anxiety Scale(HA-MA)and Beck Anxiety Inventory(BAI)were used to evaluate the severity of clinical symptoms.The cognitive function of all subjects was evaluated by Digit Symbol Substitution Test(DSST),Digita Span Test(DST),Seman-tic Verbal Fluency task(SVF)and Phonological Verbal Fluency task(PVF).Subjects were monitored for prefrontal and bilateral temporal lobe hemodynamic characteristics during the VFT using functional near-infrared spectroscopy.Results:Compared with controls,the DSST scores(P＜0.001),PVF total scores(P＜0.001),and prefrontal lobe integral values(P＜0.05)were lower in the MDD group than in the normal control group.The pre-frontal center of gravity values in the MDD group were positively correlated with the HAMD retardation factor scores(r=0.33,P＜0.05),while the bilateral temporal lobe integral values were negatively correlated with the HAMD hopelessness factor scores(r=-0.35,P＜0.05).Conclusion:Patients with MDD exhibit notable cogni-tive impairment,and the hemodynamic characteristics of their frontal and temporal lobes are correlated with the se-verity of their clinical symptoms.