RT-3DE联合血清Galectin-3及可溶性sST2对急性心肌梗死患者经皮冠状动脉介入术预后的评估价值OA

Objective To analyze the evaluation value of real-time three-dimensional echocardiography(RT-3DE)combined with serum galectin-3(Galectin-3)and soluble growth stimulation expressed gene 2 protein(sST2)in the prognosis of acute myocardial infarction(AMI)patients undergoing percutaneous coronary intervention(PCI).Methods A total of 102 AMI patients who underwent PCI in our hospital from January 2022 to January 2024 were selected as the research objects.All patients underwent preoperative RT-3DE examination to record left ventricular function indicators including left ventricular end-diastolic volume(LEDV),left ventricular end-systolic volume(LESV),and left ventricular ejection fraction(LVEF).Serum levels of Galectin-3 and sST2 were detected.Patients were followed up for 1 year after surgery.Those with death,stroke,in-stent thrombosis,recurrent myocardial infarction,re-revascularization,or bleeding were assigned to the poor prognosis group(n=42),and the others to the good prognosis group.RT-3DE results,Galectin-3 and sST2 levels were compared between the two groups(n=60).Logistic regression was used to analyze risk factors for poor prognosis,and ROC curve was adopted to evaluate the predictive value of RT-3DE combined with serum Galectin-3 and soluble sST2 for the prognosis of AMI patients after PCI.Results Specifically,the preoperative levels of LEDV,LESV,Galectin-3 and sST2 in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05),while the LVEF level was significantly lower(P＜0.05).Results of logistic regression analysis indicated that elevated LEDV[(OR)=1.076(95％CI:1.005,1.151)],elevated LESV[(OR)=1.290(95％CI:1.075,1.549)],decreased LVEF[(OR)=0.749(95％CI:0.630,0.890)],elevated Galectin-3[(OR)=1.281(95％CI:1.096,1.498)]and elevated sST2[(OR)=1.312(95％CI:1.146,1.502)]were all independent risk factors for poor prognosis in patients(P＜0.05).Receiver operating characteristic(ROC)curve analysis demonstrated that real-time three-dimensional echocardiography(RT-3DE)combined with serum Galectin-3 and sST2 had high predictive value for the prognosis of AMI patients after PCI,with a sensitivity of 92.9％(95％CI:0.805,0.985)and a specificity of 90.0％(95％CI:0.795,0.962)and the area under the curve of 0.969(95％CI:0.942,0.997).Conclusion RT-3DE combined with serum Galectin-3 and sST2 can effectively evaluate the prognosis of acute myocardial infarction patients undergoing PCI.