普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响OA

Objective To explore and analyze the efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism,its impact on thyroid function.Methods Patients with hyperthyroidism were collected and assigned into treatment group and control group.The control group was treated with iodine-131 alone;the treatment group was treated with a combination of propranolol and iodine-131.The efficacy,anxiety(self-rating anxiety scale,SAS)scores and depression(self-rating depression scale,SDS)scores,thyroid hormone levels,cardiac function indicators,and adverse reactions were compared between the two groups.Results A total of 160 patients were enrolled,with 80 cases in each group.There was no significant difference in efficacy between the treatment group and the control group(P＞0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).After treatment,the SAS score,SDS score,free triiodothyronine(FT3)level,free thyroxine(FT4)level,left ventricular ejection fraction(LVEF)level,stroke volume(SV)level,heart rate level in both groups decreased,and the treatment group was lower than the control group(all P＜0.05);the TSH level increased,and the treatment group was higher than the control group(P＜0.05).Conclusion Compared with the use of iodine-131 alone,the combined treatment of propranolol and iodine-131 for hyperthyroidism can effectively improve thyroid function and cardiac function,and reduce anxiety and depression in patients.