基于电阻抗断层成像技术评估膈神经-腹肌电刺激对脑卒中患者肺通气分布的效果OA

Objective To quantitatively evaluate the effect of phrenic nerve-abdominal muscle electrical stimulation on pulmonary ventilation distribution in stroke patients using electrical impedance tomography(EIT). Methods Thirty-five stroke patients were enrolled at the First Affiliated Hospital of Chongqing Medical University from September,2024 to June,2025,and all received standardized phrenic nerve-abdominal muscle electrical stimula-tion.Percentage of ventilation in gravity-dependent regions of interesting(ROI%),center of ventilation(COV),global inhomogeneity index(GI)and change in end-expiratory lung impedance(ΔEELI)were measured with EIT monitoring before treatment(T0),immediately after treatment(T1),and at five,ten,15,20,25,30,40 and 50 minutes after treatment(T2 to T9). Results There were significant differences in ROI%(F=7.003,P<0.001)and COV(F=5.722,P<0.001)at different time points,both peaking at T1,followed by a downward trend until T5.No significant differences were ob-served in GI(F=1.849,P=0.097)and ΔEELI(F=0.208,P=0.871)across time points;however,GI at T7 was lower than that at T0(P<0.05). Conclusion Phrenic nerve-abdominal muscle electrical stimulation can improve the ventilation ratio in gravity-depen-dent regions and shift the center of ventilation dorsally.The improvement in ventilation distribution generally peaks at the end of treatment and lasts for approximately 20 minutes.