女性膝骨关节炎患者维生素D水平及影响因素的研究OA

Objects To analyze the characteristics of vitamin D(Vit D)and identify factors influencing Vit D deficiency in patients with knee osteoarthritis(KO A).Methods Patients diagnosed with KOA between January 2018 and December 2023 were enrolled as study subjects.A total of 260 KOA patients with available Vit D test records were included,consisting of 214 females and 46 males,with a mean age of(71.95±8.35)years and a median disease duration of 5(4.00,9.00)years.Differ-ences in the severity of Vit D deficiency between the general population and KOA patients,as well as changes in Vit D levels at different stages of KOA progression,were compared.Multivariate Logistic regression and nested analysis were used to investi-gate the influencing factors of Vit D in female patients with KOA.Results A total of 260 KOA patients were included.The me-dian Vit D level was 17.31(12.45,25.91)ng·mL-1.The numbers of patients with normal,insufficient,and deficient Vit D were 35,74,and 151,respectively.Multivariate Logistic regression analysis showed that Vit D levels in KOA patients were influ-enced by female sex(OR=3.909,95％CI(0.490,2.236),P=0.002),imaging grading(OR=17.486,95％CI(0.220,5.503),P=0.034),and osteoporosis(OR=0.134,95％CI(3.381,-0.635),P=0.004).Nested analysis demonstrated that osteoporosis with Vit D supplementation reduced the risk of Vit D deficiency(OR=0.094,P=0.014),while a history of fracture increased the risk of Vit D deficiency(OR=5.750,P=0.015).Conclusion Female patients with KOA are susceptible to Vit D deficiency,with Vit D levels influenced by imaging grading,osteoporosis status,and fracture history.Regular monitoring and supplementation of Vit D in female KOA patients may delay the progression of the disease.