动脉粥样硬化性心血管疾病的炎症机制及临床转化新进展OA

Atherosclerotic cardiovascular disease is one of the major fatal diseases in the world,and its pathological basis is chronic inflammation in essence.A large amount of evidence shows that inflammation plays a key role in the oc-currence and development of atherosclerosis,in which immune cells and inflammatory signal pathways jointly regulate the inflammatory microenvironment in the blood vessels,thereby accelerating the process of disease.However,current targe-ted anti-inflammatory applications are still limited by issues such as limited targets,lack of inflammatory monitoring indica-tors,and treatment safety.This article focuses on the inflammatory mechanism of atherosclerotic cardiovascular disease,systematically reviews the regulatory role of immune cells and inflammatory signaling pathways on its inflammatory process,and discusses the potential clinical transformation strategies from multiple dimensions such as the clinical application of new inflammatory markers and targets,precision intervention technology,and lifestyle management,which provides a new idea for building an accurate prevention and treatment system targeting inflammation.