枳壳"成分—药理—质控—炮制"研究热点与趋势的文献计量学分析OA

Objective To map and quantitatively analyze the research on Zhiqiao(Aurantii Fructus)using bibliometric methods,and to deeply investigate the dynamic evolution of research topics through a systematic review,thereby identifying current research hotspots,frontier areas,and future directions.Methods China National Knowledge Infrastructure(CNKI)and Web of Science(WOS)Core Collection were used as data sources to retrieve research literature related to Zhiqiao(Aurantii Fructus)published from January 1,2005,to October 12,2025.CiteSpace 6.4 software was employed to perform keyword co-occurrence,clustering,and timeline analyses,and a systematic review was conducted on the four major research modules characterized by high-frequency keywords.Results A total of 648 Chinese and 298 English articles were included,with a steady annual increase in publication numbers.Chinese research centered on the"neohesperidin-fingerprint-quality standard"chain,while English studies focused on"flavonoids-antioxidant activity-mass spectrometry".Cluster analysis identified four major modules,namely chemical composition(flavonoids,volatile oils,alkaloids,polysaccharides,triterpenoids),pharmacological effects(gastrointestinal regulation,cardiovascular protection,anti-inflammatory and immune effects),quality control(fingerprint-multi-index quantitative comprehensive evaluation),and processing technology(e.g.,bran frying and its modulation of the component profile and efficacy).Timeline analysis indicated a shift from basic analysis to mechanistic deepening.Conclusion Research on Zhiqiao(Aurantii Fructus)exhibits multidisciplinary characteristics.Chinese research emphasizes the application framework of"component analysis-quality control standards",while English research focuses on in-depth exploration of"active components-pharmacological mechanisms".The two paradigms complement each other,jointly forming the core research landscape of this field.