生长抑素联合卡络磺钠、兰索拉唑对老年PUB患者氧化应激指标及血清VEGF水平的影响OA
Effects of somatostatin combined with carbazochrome sodium sulfonate and lansoprazole on oxidative stress indicators and serum VEGF levels in elderly patients with PUB
目的 探讨生长抑素联合卡络磺钠、兰索拉唑对老年消化性溃疡出血(PUB)患者氧化应激指标及血清血管内皮生长因子(VEGF)水平的影响.方法 选取2021年3月2024年6月重庆医科大学附属永川医院消化内科收治的老年PUB患者150例,以随机数字表法分为对照组与观察组,各75例;对照组予卡络磺钠、兰索拉唑治疗,观察组予生长抑素联合卡络磺钠、兰索拉唑治疗;治疗5 d后,比较2组的治疗效果,观察凝血指标[纤维蛋白原(Fib)、凝血酶时间(TT)、凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)]、氧化应激指标[超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)、氧化低密度脂蛋白(ox-LDL)、丙二醛(MDA)]、血清酪酪肽(PYY)、VEGF、热休克蛋白-70(HSP-70)水平变化,记录止血时间、总住院时间及不良反应发生率.结果 观察组治疗总有效率为94.67％,高于对照组的 80.00％(x2=7.292,P=0.007);治疗 5 d 后,观察组 Fib、SOD、VEGF、HSP-70 水平高于对照组(t/P=5.938/＜0.001、7.756/＜0.001、6.661/＜0.001、7.528/＜0.001),TT、PT、APTT、AOPP、ox-LDL、MDA、PYY 水平短于/低于对照组(t/P=7.566/＜0.001、9.657/＜0.001、10.186/＜0.001、4.882/＜0.001、6.238/＜0.001、8.941/＜0.001、12.220/＜0.001);观察组止血、总住院时间短于对照组(t=5.983、18.752,P均＜0.001);观察组不良反应发生率为14.67％,与对照组(9.33％)比较,差异无统计学意义(P＞0.05).结论 老年PUB患者采用生长抑素联合卡络磺钠、兰索拉唑治疗效果较好,可改善凝血指标,降低氧化应激反应,调节血清PYY、VEGF、HSP-70水平,缩短康复进程,且药物安全性好.
Objective To investigate the effects of somatostatin combined with carbazochrome sodium sulfonate and lansoprazole on oxidative stress indicators and serum vascular endothelial growth factor(VEGF)levels in elderly patients with peptic ulcer bleeding(PUB).Methods A total of 150 elderly PUB patients admitted to the Department of Digestive Medi-cine,Yongchuan Hospital of Chongqing Medical University from March 2021 to June 2024 were selected and divided into a control group and a treatment group using a random number table,with 75 cases in each group.The control group received carbazochrome sodium sulfonate and lansoprazole,while the treatment group received somatostatin combined with carbazo-chrome sodium sulfonate and lansoprazole.The therapeutic efficacy,coagulation indices[fibrinogen(Fib),thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)],oxidative stress indicators[superoxide dismutase(SOD),advanced oxidation protein products(AOPP),oxidized low-density lipoprotein(ox-LDL),malondialdehyde(MDA)],serum levels of peptide YY(PYY),VEGF,heat shock protein-70(HSP-70),hemostasis time,total hospital stay,and adverse reactions were compared between the two groups.Results The total effective rate was significantly higher in the treatment group(94.67％)than in the control group(80.00％)(x2=7.292,P=0.007).After 5 days of treatment,the levels of Fib,SOD,VEGF,and HSP-70 in the treatment group were significantly higher than those in the control group,while the levels of TT,PT,APTT,AOPP,ox-LDL,MDA,and PYY were significantly lower than those in the control group(t=5.938,7.756,6.661,7.528,7.566,9.657,10.186,4.882,6.238,8.941,12.220,all P＜0.001).The hemostasis time and total hospital stay were signifi-cantly shorter in the treatment group than in the control group(t=5.983,18.752,both P＜0.001).There was no statistically sig-nificant difference in the incidence of adverse reactions between the treatment group(14.67％)and the control group(9.33％)(P＞0.05).Conclusion The combination of somatostatin,carbazochrome sodium sulfonate,and lansoprazole demonstrates fa-vorable efficacy in treating elderly PUB patients.It can improve coagulation indices,reduce oxidative stress response,modulate serum levels of PYY,VEGF,and HSP-70,shorten the recovery process,and exhibits good drug safety.
殷洪波;谭柯馨;龙玲;曾杰;何平
402160 重庆,重庆医科大学附属永川医院消化内科402160 重庆,重庆医科大学附属永川医院消化内科402160 重庆,重庆医科大学附属永川医院消化内科402160 重庆,重庆医科大学附属永川医院消化内科402160 重庆,重庆医科大学附属永川医院消化内科
医药卫生
消化性溃疡出血生长抑素卡络磺钠兰索拉唑疗效老年人
Peptic ulcer bleedingSomatostatinCarbazochrome sodium sulfonateLansoprazoleTherapeutic effica-cyElderly
《疑难病杂志》 2026 (5)
552-556,5
国家自然科学基金青年基金资助项目(82102250)重庆市科卫联合医学科研项目(CSTB2022NSCQ-MSX1440) Youth Program of the National Natural Science Foundation of China(82102250)Chongqing Joint Medical Research Project of Science and Health(CSTB2022NSCQ-MSX1440)
评论