缺血性脑卒中患者血清CGN、FNDC5、PAR4水平与病情及并发血管性认知功能障碍的相关性OA

Objective The correlation between the levels of serum corticotropin-releasing factor(CGN),type Ⅲ fi-bronectin domain protein 5(FNDC5),and platelet-activating protease-activating receptor 4(PAR4)in patients with ischemic stroke(IS)and their disease condition as well as the concurrent vascular cognitive dysfunction(VCI)was analyzed.Methods One hundred and three patients with IS admitted to the Neurology Department of Yan'an University Affiliated Hospital from July 2023 to July 2025 were selected as the IS group.They were divided into mild(n=26),moderate(n=35),moderately severe(n=22),and severe(n=20)based on the severity of the disease,and were further divided into the VCI subgroup(n=32)and the non-VCI subgroup(n=71)according to the occurrence of VCI.105 healthy individuals who underwent physical examinations at the same hospital during the same period were recruited as the CT group.ELISA was used to detect the levels of serum CGN,FNDC5,and PAR4;relative risk analysis was conducted to identify the factors influencing the concurrent VCI in IS patients;ROC analysis was performed to evaluate the predictive value of serum sCGN,FNDC5,and PAR4 for VCI.Re-sults The results showed that the serum levels of CGN and PAR4 in the IS group were higher than those in the CT group,while the serum level of FNDC5 was lower than that in the CT group(t/P=50.227/＜0.001,24.772/＜0.001,40.118/＜0.001);the serum levels of CGN and PAR4 increased successively in patients with mild,moderate,moderate-severe,and severe condi-tions,while the serum level of FNDC5 decreased successively(F/P=165.761/＜0.001,179.691/＜0.001,166.107/＜0.001);com-pared with the NVCI sub-group,the serum levels of CGN,PAR4,and FNDC5 in the VCI sub-group were higher than those in the NVCI sub-group,while the serum level of FNDC5 was lower(t/P=7.180/＜0.001,7.303/＜0.001,7.193/＜0.001);patients with high serum levels of CGN,FNDC5,and PAR4 had a 1.947-fold,0.463-fold,and 2.506-fold higher risk of developing VCI compared to those with low serum levels of CGN,FNDC5,and PAR4;the AUCs of serum CGN,FNDC5,PAR4,and their combination for predicting VCI in IS patients were 0.848,0.850,0.856,and 0.921,respectively,and the AUC of the com-bination of the three was larger(Z/P=2.264/0.024,2.763/0.010,2.521/0.015).Conclusion The levels of serum CGN and PAR4 increase and the level of FNDC5 decreases in patients with IS.All are related to the severity of the disease and have certain predictive value for IS complicated with VCI.