高危前列腺癌大分割放疗中的HT与VMAT计划对比研究OA

Objective To compare the dosimetric characteristics of helical tomotherapy(HT)and volumetric modulated arc therapy(VMAT)plans for high-risk prostate cancer hypofractionated radiotherapy,so as to provide guidance to select a radiotherapy modality for patients with high-risk prostate cancer.Methods A total of 62 patients who underwent radical radiotherapy for prostate cancer at the Department of Radiation Oncology of some hospital between May 2022 and July 2024 were selected,and for each patient two separate treatment plans were designed:an HT plan using the Accuray Tomotherapy System(TOMO)and a VMAT plan using the Elekta Monaco treatment planning system.The prescribed dose to the target volume was 70 Gy for both plans,and the dose to the pelvic lymph node drainage area was 50.4 Gy,delivered in 28 concurrent fractions.The two plans were compared in terms of the target volume dosimetric parameters,doses to organs at risk(OARs)and beam-on time for single treatment.Statistical analysis was performed using SPSS 23.0 software.Results The HT plan had the target volume dose Dmax lower while the conformity index(CI)and homogeneity index(HI)better than those of the VMAT plan,with the differences being statistically significant(P<0.001);the rectal V45,V55 and V65,the bladder V50,the femoral head V50 and the small intestine Dmax were all lower in the HT plan than in the VMAT plan,with the differences being statistically significant(P<0.05);the HT plan had the beam-on time for single treatment slightly longer than that of the VMAT plan,with the differences being statistically significant(P<0.05).Conclusion The HT plan behaves better than the VMAT plan for high-risk prostate cancer hypofractionated radiotherapy in terms of target volume dose distribution and OAR protection.HT-based hypofractionated radiotherapy plan may be preferred for patients with high-risk prostate cancer who require irradiation of the pelvic lymphatic drainage area.[Chinese Medical Equipment Journal,2026,47(5):57-61]