基于强迫振荡技术的肺功能测量装置设计OA
Design of pulmonary function measurement device based on forced oscillation technique
目的:为实现慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的早期诊断,提升检测舒适度和设备便携性,设计一种基于强迫振荡技术的便携式肺功能测量装置.方法:肺功能测量装置选用丙烯腈-丁二烯-苯乙烯共聚物(acrylonitrile butadiene styrene,ABS)工程塑料制作外壳,以STM32F103作为主控芯片,硬件部分由传感器采集模块、振荡模块及电源模块组成.传感器采集模块选用2个SM7391数字式压差传感器;振荡模块主要由波形生成单元、信号整流电路和功率放大电路构成,核心执行元件为扬声器;电源模块通过24 V直流电源适配器供电,内部设有以TPS54560芯片为核心的电源管理电路.该装置的程序设计可分为下位机嵌入式部分和上位机应用部分.下位机嵌入式部分采用C语言在Keil μVision开发环境下编写,上位机应用部分基于MATLAB平台的App Designer模块进行开发.为验证该装置测量肺功能参数的准确性,将其与标准商用临床肺功能仪进行对比,并进行Bland-Altman分析和线性回归分析.结果:Bland-Altman分析和线性回归分析表明,该装置测量的核心呼吸阻抗参数与临床肺功能仪具有高度的一致性,能够满足临床对于气道阻抗评估的准确性要求.结论:基于强迫振荡技术的肺功能测量装置能够准确测量呼吸阻力、电抗、共振频率及电抗面积等肺功能参数,可为呼吸系统疾病的早期诊断与动态监测提供可靠的技术支持.
Objective To design a portable pulmonary function measurement device based on the forced oscillation technique,so as to enable the early diagnosis of chronic obstructive pulmonary disease(COPD)and improve patient comfort and device portability.Methods The portable pulmonary function measurement device had its housing made of acrylonitrile-butadiene styrene(ABS)engineering plastic and a STM32F103 as the main control chip,which was composed of a sensor acquisition module,an oscillation module and a power supply module.The sensor acquisition module consisted of two SM7391 digital differential pressure sensors;the oscillation module primarily comprised a waveform generation unit,a signal rectification circuit and a power amplification circuit,with a speaker serving as the core executive component;the power supply module was powered by a 24 V DC power adapter and incorporated a power management circuit centered around the TPS54560 chip.The software of the device was divided into a lower embedded system component and a host-based application component.The lower embedded system was programmed using the C programming language under the Keil μVision development environment,and the host-based application component was developed using the App Designer module on the MATLAB platform.To verify the accuracy of the device's pulmonary function measurements,it underwent comparison with a standard commercial clinical spirometer and analysis by Bland-Altman plots and linear regression.Results Bland-Altman and linear regression analyses indicated that the core respiratory impedance parameters measured by this device showed a high degree of agreement with those from the clinical spirometer,thereby meeting clinical requirements for accuracy in airway impedance assessment.Conclusion The pulmonary function measurement device based on the forced oscillation technique accurately measures pulmonary function parameters such as respiratory resistance,reactance,resonance frequency and reactance area,providing reliable technical support for the early diagnosis and dynamic monitoring of respiratory diseases.[Chinese Medical Equipment Journal,2026,47(5):21-28]
王梦源;刘秉鑫;林俊杰;殷涛;刘志朋;张顺起
中国医学科学院生物医学工程研究所,先进医用材料与医疗器械全国重点实验室,天津市神经调控与修复重点实验室,天津医学健康科学研究院,呼吸与危重症诊疗技术与器械教育部工程研究中心,天津 300192中国医学科学院生物医学工程研究所,先进医用材料与医疗器械全国重点实验室,天津市神经调控与修复重点实验室,天津医学健康科学研究院,呼吸与危重症诊疗技术与器械教育部工程研究中心,天津 300192中国医学科学院生物医学工程研究所,先进医用材料与医疗器械全国重点实验室,天津市神经调控与修复重点实验室,天津医学健康科学研究院,呼吸与危重症诊疗技术与器械教育部工程研究中心,天津 300192中国医学科学院生物医学工程研究所,先进医用材料与医疗器械全国重点实验室,天津市神经调控与修复重点实验室,天津医学健康科学研究院,呼吸与危重症诊疗技术与器械教育部工程研究中心,天津 300192中国医学科学院生物医学工程研究所,先进医用材料与医疗器械全国重点实验室,天津市神经调控与修复重点实验室,天津医学健康科学研究院,呼吸与危重症诊疗技术与器械教育部工程研究中心,天津 300192中国医学科学院生物医学工程研究所,先进医用材料与医疗器械全国重点实验室,天津市神经调控与修复重点实验室,天津医学健康科学研究院,呼吸与危重症诊疗技术与器械教育部工程研究中心,天津 300192
医药卫生
肺功能检测肺功能测量装置强迫振荡技术慢性阻塞性肺疾病便携医疗设备
pulmonary function measurementpulmonary function measurement deviceforced oscillation techniquechronic obstructive pulmonary diseaseportable medical device
《医疗卫生装备》 2026 (5)
21-28,8
国家重大科研仪器研制项目(81927806)中国医学科学院医学健康前沿交叉研究专项(2023-I2M-QJ-017)天津市自然科学基金项目(24JCYBJC00570)北京协和医学院中央高校基本科研业务费专项资金资助项目(3332025197)中国博士后科学基金会博士后资助项目(GZC20251897,2025M772880)
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